A Study of the Safety and Efficacy of Depakote ER Plus an Atypical Antipsychotic Vs. an Atypical Antipsychotic Alone in the Treatment of Schizophrenia
Collecte de données
Troubles Mentaux
+ Schizophrénie
+ Troubles du Spectre de la Schizophrénie et Autres Troubles Psychotiques
Étude thérapeutique
Résumé
Date de début de l'étude : 1 juillet 2003
Date à laquelle le premier participant a commencé l'étude.The purpose of this study is to assess the 14-day and 12-week safety and efficacy of Depakote ER used in combination with either olanzapine or risperidone versus antipsychotic monotherapy with olanzapine or risperidone for the treatment of schizophrenia.
Protocole
Cette section fournit des détails sur le plan de l'étude, y compris la manière dont l'étude est conçue et ce qu'elle évalue.400 participants à inclure
Nombre total de participants que l'essai clinique vise à recruter.Traitement
Éligibilité
Les chercheurs recherchent des patients correspondant à une certaine description appelée critères d'éligibilité : état de santé général ou traitements antérieurs du patient.Tout sexe
Le sexe biologique des participants éligibles à s'inscrire.De 18 à 65 ans
Tranche d'âge des participants éligibles à participer.Volontaires sains non autorisés
Indique si les individus en bonne santé et ne présentant pas la condition étudiée peuvent participer.Conditions
Pathologie
Critères
KEY INCLUSION CRITERIA: * Acute exacerbation of schizophrenia as defined by: subject recently hospitalized or is in the process of being admitted to a hospital or an acute care inpatient psychiatric treatment facility; and has a PANNS Total score of 70 or greater at the time of screening and at randomization based on a 1-7 point scale; and has a score on any two of the four items from psychosis cluster of the BPRS (extracted from the PANSS) that correspond to the positive symptoms (hallucinatory behavior, unusual thought content, conceptual disorganization and suspiciousness) totaling 8 or greater; and has a total of 6 or greater on one of the following two pairs of items from the BPRS (extracted from the PANSS): hostility and uncooperativeness or excitement and tension. * Current DSM-IV-TR diagnosis of schizophrenia as confirmed by the SCID * Positive response to antipsychotics in the previous 2 years KEY EXCLUSION CRITERIA: * Current diagnosis of schizoaffective disorder, drug-induced psychosis, manic episode or major depressive episode. * At the time of screening, has been hospitalized for more than 14 days for the current episode * Has ever taken clozapine * Has had more than 3 psychiatric hospitalizations in the previous 6 months or has had more than 8 weeks of psychiatric hospitalization in the previous 12 months * Has serious violent, homicidal, suicidal ideation * Has received depot medications fluphenazine decanoate and/or haloperidol decanoate within 2 or 4 weeks prior to randomization respectively * Urine toxicology screen is positive for phencyclidine (PCP), opiates, cocaine or amphetamines * History of alcohol or substance dependence within the past month * Has taken any valproate product for a psychiatric indication within the previous 30 days * Has received an investigational drug within the last 30 days
Plan de l'étude
Découvrez tous les traitements administrés dans cette étude, leur description détaillée et ce qu'ils impliquent.Objectifs de l'étude
Objectifs principaux
Objectifs secondaires