Phantom Pain: A Therapeutic Trial Using Transcranial Magnetic Stimulation
Collecte de données
Maladies du système nerveux+8
+ Manifestations Neurologiques
+ Douleur Postopératoire
Étude thérapeutique
Résumé
Date de début de l'étude : 1 décembre 1998
Date à laquelle le premier participant a commencé l'étude.Phantom pain is a chronic painful condition that affects patients with amputations. Treatment for phantom pain is often disappointing. In amputees, hyperexcitability of the posterior parietal cortex area (PPC) contralateral to the side of the amputation has been linked with the presence of phantom sensations. PPC is an area overactive in different forms of chronic pain too. It is therefore conceivable that downregulation of activity in PPC could improve phantom limb pain, a condition poorly responsive to available treatments. We have previously demonstrated that low frequency TMS (1 Hz) results in decreased excitability of the stimulated cortical regions. We plan to apply low-frequency TMS to PPC cortical areas contralateral to the side of the amputated limb. We expect that this intervention will result in amelioration of the phantom pain. Stimulation of the PPC area (target intervention) will be compared with a control intervention in which TMS is directed slightly away from the head.
Protocole
Cette section fournit des détails sur le plan de l'étude, y compris la manière dont l'étude est conçue et ce qu'elle évalue.20 participants à inclure
Nombre total de participants que l'essai clinique vise à recruter.Traitement
Éligibilité
Les chercheurs recherchent des patients correspondant à une certaine description appelée critères d'éligibilité : état de santé général ou traitements antérieurs du patient.Tout sexe
Le sexe biologique des participants éligibles à s'inscrire.Volontaires sains non autorisés
Indique si les individus en bonne santé et ne présentant pas la condition étudiée peuvent participer.Conditions
Pathologie
Critères
Patients must be between 18 and 65 years of age. Patients must have amputations and phantom pain for at least 12 months. Patient's pain should be at least moderate and be present at least 8 hours per day or severe lasting for at least 2 hours per day. Patients must not have had a previous stroke or brain lesions. Patients must not have severe depression, poor motivational capacity. Patients must not have serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 20 or less). Patients must not have severe uncontrolled medical problems (e.g. cardiovascular disease, any kind of end-stage pulmonary or cardiovascular disease, or epilepsy). Patients must not have a personal history of seizures or other neurological disorders. Women must not be pregnant. Patients must not have severe coronary disease. Patients must not have metal in the cranium except mouth. Patients must not have intracardiac lines. Patients must not have increased intracranial pressure as evaluated by clinical means. Patients must not have cardiac pacemakers. Patients must not be taking neuroleptics.
Centres d'étude
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National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, United StatesOuvrir National Institute of Neurological Disorders and Stroke (NINDS) dans Google Maps