Evaluation of Electromechanical Endocardial Mapping for Assessment of Myocardial Ischemia and Viability
FDG
+ NH(3)
Maladies Cardiovasculaires+1
+ Maladies Cardiaques
+ Maladies vasculaires
Étude thérapeutique
Résumé
Date de début de l'étude : 1 août 1999
Date à laquelle le premier participant a commencé l'étude.A novel left ventricular (LV) mapping system (Biosense, Inc.) uses low-intensity magnetic field energy to determine the location of sensor-tipped catheter electrodes within the LV. On the basis of previous experimental and human studies correlating the extent of myocardial ischemia with the amplitude of electrical signals, we hypothesize that such an integrated LV electromechanical mapping system could be used to distinguish healthy from ischemic or immobile myocardium on the basis of the extent of electromechanical endocardial signals. If this hypothesis is confirmed, the ability to detect on-line myocardial viability and ischemia in the catheterization laboratory may be feasible. The present study attempts to distinguish between ischemic, immobile, and normal myocardium by comparing LV electromechanical mapping data at rest and during pharmacologic stimulation, with imaging studies using MRI, PET, thallium and echo in patients with coronary artery disease.
Protocole
Cette section fournit des détails sur le plan de l'étude, y compris la manière dont l'étude est conçue et ce qu'elle évalue.71 participants à inclure
Nombre total de participants que l'essai clinique vise à recruter.Traitement
Éligibilité
Les chercheurs recherchent des patients correspondant à une certaine description appelée critères d'éligibilité : état de santé général ou traitements antérieurs du patient.Tout sexe
Le sexe biologique des participants éligibles à s'inscrire.Volontaires sains non autorisés
Indique si les individus en bonne santé et ne présentant pas la condition étudiée peuvent participer.Conditions
Pathologie
Critères
Male or female patients greater than or equal to 21 years undergoing diagnostic cardiac catheterization. Must not have unstable angina. No significant unprotected left main disease (greater than 50% stenosis). No recent myocardial infarction (less than 4 weeks). Females must not be pregnant or lactating. No chronic atrial fibrillation. No prosthetic heart valves. No significant aortic valve pathology (sclerosis or stenosis) which might prevent retrograde crossing of catheter across the aortic valve. No left ventricular thrombus seen on echo. No severe heart failure (NYHA Class 4). No severe ectopy (greater than 1 every 10 beats) or ventricular tachycardia. No active infections (fever and elevated white cell count). Patients will not be considered for this protocol because of contraindications to MRI scan, as stated below: Pacemaker Implanted defibrillator Cerebral aneurysm clips Swan Ganz catheter with electrodes for a thermistor Cochlear implants Insulin pumps Neural stimulator
Centres d'étude
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National Heart, Lung and Blood Institute (NHLBI)
Bethesda, United StatesOuvrir National Heart, Lung and Blood Institute (NHLBI) dans Google Maps