Phase I Study of Corticosteroid Treatment of Ill-Defined Choroidal Neovascularization in Age-Related Macular Degeneration

Date de début de l'étude : 1 juillet 1997

Diagnosis of AMD defined by the presence of drusen in one eye and age over 50. Vision 20/400 or worse in the fellow eye due to exudative complications from CNVM under the fovea. Visual acuity of 20/80 - 20/200 in the study eye. Ineligibility for a clinically proven laser photocoagulation protocol. No patients with age less than 50. No patients with previous laser therapy for surgery for choroidal neovascularization in the study eye. No patients with choroidal neovascularization, in the study eye, associated with other ocular diseases such as pathologic myopia, ocular histoplasmosis, posterior uveitis, idiopathic, etc. No patients with presence of geographic atrophy or serous pigment epithelial detachment under the fovea in the study eye. No patients with decreased vision, in the study eye, due to retinal disease not attributable to ill-defined CNVM, such as serous retinal pigment epithelial detachment, nonexudative form of ARM, geographic atrophy, inherited retinal dystrophy, uveitis, epiretinal membrane and others. No patients with decreased vision, in the study eye, due to significant media opacity such as corneal disease or cataract. No patients with systemic or local therapy that may alter the natural course of ill-defined CNVM, especially antiangiogenic treatment with thalidomide or alpha interferon. No patients with intraocular pressure greater than or equal to 26 or history suggesting glaucoma (e.g., history of the diagnosis of glaucoma, past or present use of medications to control intraocular pressure, or disc/nerve fiber layer defects suggestive of glaucoma) and glaucomatous visual field defects as documented by Goldmann or Humphrey perimetry taken within 6 months to qualification. No patients with any contraindications to performing the necessary diagnostic studies, especially the use of fluorescein angiography. No patients with known history of untoward complications from corticosteroid therapy, including elevated intraocular pressure in response to topical or periocular corticosteroids. No patients with medical problems which make consistent follow-up over the treatment period unlikely (e.g., stroke, severe MI, terminal carcinoma. No patients with current use of or likely need for systemic or ocular medications known to be toxic to the lens, retina or optic nerve, such as: Deferoxamine, Chloroquine/Hydroxychloroquine (Plaquenil), Tamoxifen, Chlorpromazine, Phenothiazines, Ethambutol, Ocular or systemic steroids or use of steroid-containing inhalers or nasal sprays utilized more than 6 days a month on average-any regular use of pills containing steroids.