Cytokine Expression in Allergic Asthma

Date de début de l'étude : 14 septembre 1994

INCLUSION CRITERIA - BLOOD DRAW/ASTHMA: Age 18-65. Asthma of greater than one year duration. Willingness to adhere to effective contraception in women of child bearing age. Negative HIV test. EXCLUSION CRITERIA - BLOOD DRAW/ASTHMA: For blood draws of greater than 100 ml, a hemoglobin of less than 12.5 g/dl. For blood draws of 100 ml or less, performed less frequently than every 56 days, a hemoglobin of less than 10.0 g/dl. Current pregnancy. Medical history suggesting lung diseases other than asthma. History of immunodeficiency or HIV infection. INCLUSION CRITERIA - BLOOD DRAW/NORMAL CONTROL: Age 18-65. Willingness to adhere to effective contraception in women of child bearing age. Negative HIV test. EXCLUSION CRITERIA - BLOOD DRAW/NORMAL CONTROL: For blood draws of greater than 100 ml, a hemoglobin of less than 12.5 g/dl. For blood draws of 100 ml or less, performed less frequently than every 56 days, a hemoglobin of less than 10.0 g/dl. Current pregnancy. Positive skin test to one or more allergens in the battery tested. History of asthma or other allergic diseases, such as hay fever. Medical history suggesting lung diseases other than asthma. History of immunodeficiency or HIV infection. INCLUSION CRITERIA - EXHALED BREATH CONDENSATE/ASTHMA: Age 18-65. Asthma as diagnosed by a physician or use of medications consistent with the treatment of asthma. Subjects must have a doctor outside NIH and they will provide routine and emergency care. EXCLUSION CRITERIA - EXHALED BREATH CONDENSATE/ASTHMA: History of immunodeficiency or HIV infection. History of allergy to latex. INCLUSION CRITERIA - EXHALED BREATH CONDENSATE/HEALTHY CONTROL: Age 18 - 65. EXCLUSION CRITERIA - EXHALED BREATH CONDENSATE/HEALTHY CONTROL: History of asthma or other allergic diseases, such as allergic rhinitis. Medical history suggesting lung diseases other than asthma. History of allergy to latex. History of immunodeficiency or HIV infection.