Active Immunization of HIV-1 Infected, Pregnant Women With CD4 Lymphocyte Counts >= 400/mm3: A Phase I Study of Safety and Immunogenicity of MN rgp120/HIV-1 Vaccine (NOTE: Some Patients Receive Placebo)
rgp120/HIV-1MN
Infections transmises par le sang+14
+ Maladies génito-urinaires
+ Maladies Génitales
Étude de prévention
Résumé
Evidence suggests that an advanced stage of disease with high plasma viremia is associated with increased transmission of HIV-1 to the fetus. Slowing the progression of disease, reducing the titer of virus in plasma, and increasing the titer of epitope-specific antibody are potentially attainable goals through active immunization of the mother during pregnancy. Pregnant women are randomized to receive an initial injection of MN rgp120 vaccine or alum placebo between week 16 and week 24 of gestation, followed by monthly booster injections concluding at the end of pregnancy, for a total of five injections. Patients may have optional booster immunizations (vaccine or placebo) at 3, 6, 9, and 12 months after delivery. Mothers and infants are followed through 18 months after delivery. Per 06/94 addendum, patients will be contacted once or twice per year for at least 5 years to check on health status of patient and child. PER 12/21/94 ADDENDUM, post-partum immunizations are discontinued.
Protocole
Cette section fournit des détails sur le plan de l'étude, y compris la manière dont l'étude est conçue et ce qu'elle évalue.24 participants à inclure
Nombre total de participants que l'essai clinique vise à recruter.Prévention
Éligibilité
Les chercheurs recherchent des patients correspondant à une certaine description appelée critères d'éligibilité : état de santé général ou traitements antérieurs du patient.Femme
Le sexe biologique des participants éligibles à s'inscrire.De 16 à 40 ans
Tranche d'âge des participants éligibles à participer.Volontaires sains non autorisés
Indique si les individus en bonne santé et ne présentant pas la condition étudiée peuvent participer.Conditions
Pathologie
Critères
Inclusion Criteria Concurrent Medication: Allowed: AZT. Acyclovir. Patients must have: HIV-1 infection. CD4 count >= 400 cells/mm3. No AIDS-defining illness or other systemic manifestations related to HIV (other than generalized lymphadenopathy). HIV p24 < 30 pg/ml. Proven pregnancy in the 16th to 24th week of gestation at study entry, with no special obstetrical risks. Concurrent AZT therapy is permitted. Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: Known hypersensitivity to a component of the vaccine. Evidence of fetal abnormality on ultrasound. Evidence of maternal risk factors including insulin-dependent diabetes, moderate to severe hypertension, repeated fetal wastage (> 3), Rh-sensitization or other blood group alloimmunization, severe renal disease, previous infants with malformations or other factors that obstetrically are judged to constitute a special risk of spontaneous abortion or premature birth. Active syphilis. Hepatitis B surface antigen positive. Concurrent Medication: Excluded: Antiretroviral or immunomodulating agent other than AZT during the pregnancy. Prior Medication: Excluded: Antiretroviral or immunomodulating agent other than AZT within 90 days prior to study entry. Current use of illicit drugs or known chronic alcohol use.
Centres d'étude
Ce sont les hôpitaux, cliniques ou centres de recherche où l'essai est conduit. Vous pouvez trouver le site le plus proche de vous ainsi que son statut.Cette étude comporte 6 sites
San Francisco Gen. Hosp.
San Francisco, United StatesOuvrir San Francisco Gen. Hosp. dans Google MapsUCSF Pediatric AIDS CRS
San Francisco, United StatesJohns Hopkins Hosp. & Health System - Dept. of Peds., Div. of Infectious Diseases
Baltimore, United StatesWashington U CRS
St Louis, United States