Phase I Trial of the Combination of Zidovudine and Recombinant Interleukin-2 in Patients With Persistent Generalized Lymphadenopathy

Inclusion Criteria * Detectable HIV nucleic acid in patient peripheral blood mononuclear leukocytes (PBML's) by the gene amplification technique. A positive antibody to HIV confirmed by any federally licensed ELISA test kit. Concurrent Medication: Allowed: * Medications without which there might be significant risk, such as seizures, loss of diabetic control or respiratory embarrassment. * Necessary topical agents including topical acyclovir. * Diuretics for significant fluid retention only. Concurrent Treatment: Allowed: * Blood transfusions for anemia if hematocrit falls below 25 percent. Exclusion Criteria * Active drug or alcohol abuse. Co-existing Condition: Patients with the following will be excluded: * Grade 1 impairment on two or more items in the ACTG Micro Neuro AIDS assessment. * Concurrent neoplasms other than basal cell carcinoma of the skin or in situ carcinoma of the cervix. * Major organ allograft. * Significant cardiac disease or central nervous system lesions. * Patients with hemophilia should be evaluated and treated under the hemophilia protocol. Concurrent Medication: Excluded: * Inderal or vasoactive hypertensive medication. * Non-essential medications including pain medications. Excluded are: * Patients with an opportunistic infection or malignancy fulfilling the definition of AIDS. Patients with AIDS related complex, defined as: * 1\. Weight loss in excess of 15 lbs. or 10 percent of body weight noted in a 2-year period prior to entry into the study. 2. Temperature greater than 38.5 degrees C with or without night sweats, persisting for more than 14 consecutive days or more than 15 days in a 30-day interval during a 2-year period prior to entry into the study. 3. Diarrhea defined as = or \> 3 liquid stools per day, persisting for more than 30 days during a 2-year period prior to entry into the study without a definable cause. 4. Herpes zoster during the past 2 years. 5. Oral candidiasis or biopsy-proven hairy leukoplakia during the last 2 years. 6. Active substance abuse. Prior Medication: Excluded: * Zidovudine (AZT). * Excluded within 30 days of study entry: * Antiretroviral agents. * Biologic response modifiers. * Corticosteroids. * Excluded within 60 days of study entry: * Ribavirin.