TMS Impact on LH and FSH Hormones in Healthy Women
Transcranial Magnetic Stimulation Active
+ Transcranial Magnetic Stimulation Sham
Estudio de Ciencia Básica
Resumen
Fecha de inicio: 1 de febrero de 2026
Fecha en la que se inscribió al primer participante.This research focuses on understanding whether a non-invasive procedure called Transcranial Magnetic Stimulation (TMS) can influence hormones, specifically Luteinizing Hormone (LH) and Follicle-stimulating hormone (FSH), in healthy women during the luteal phase of their menstrual cycle. The luteal phase is the second half of the menstrual cycle, following ovulation. The study aims to explore if TMS can mimic the natural hormonal signals that stimulate LH secretion, potentially leading to a better understanding of hormonal regulation. During the study, TMS is applied to a specific area of the brain known as the Dorsolateral Prefrontal Cortex. The effect of TMS is then measured by observing changes in LH and FSH levels at six different time points. Blood samples are collected for this purpose. The primary outcome of the study is to evaluate these changes in hormone levels within each participant and compare the results between active TMS and a placebo (sham) stimulation. The study does not mention any specific risks or benefits associated with participation.
Protocolo
Esta sección proporciona detalles del plan del estudio, incluyendo cómo está diseñado y qué se está evaluando.Se reclutarán 10 pacientes
Número total de participantes que el ensayo clínico espera reclutar.Estudio de Ciencia Básica
Elegibilidad
Los investigadores buscan pacientes que cumplan ciertos criterios, conocidos como criterios de elegibilidad: estado general de salud o tratamientos previos.Mujer
Sexo biológico de los participantes elegibles para inscribirse.De 22 a 40 años
Rango de edades de los participantes que pueden unirse al estudio.Voluntarios sanos permitidos
Indica si personas sanas, sin la condición que se estudia, pueden participar.Criterios
Inclusion Criteria: * Healthy women aged 22-40 years with regular menstrual cycle. * In luteal phase at the time of visit. Exclusion Criteria: * Presence of any known structural brain abnormalities or tumors. * Presence of metal implants/devices in the head or neck. * Has ever had a stroke, seizure, or has a family history of epilepsy. * Head injury with loss of consciousness. * Use of hormonal contraceptives in the past 3 months. * Irregular menstrual cycles. * Diagnosed with a reproductive system disorder (e.g., PCOS, endometriosis, infertility, hypogonadism). * History of endocrine disorders such diabetes mellitus, thyroid disease, adrenal disorders, pituitary tumor or others. * Been diagnosed or received treatment for depression, anxiety disorder, schizophrenia, PTSD or bipolar disorder. * Have a history of medical disorder such liver or renal impairment, HIV/AIDS or unstable cardiac disease. * Taking any medications that affect the central nervous system such as antidepressents, antipsychotics, GLP-1 receptor agonists or hormone therapies. * Are you pregnant, planning pregnancy or breastfeeding. * Have experienced difficulties in the past during blood draws such as locating the vein, fainting or other adverse reactions. * Have any sleep disorder such as insomnia or sleep apnea. * Have fear of needles or the sight of blood. * Underwent TMS stimulation in the past and had difficulties.
Plan de Estudio
Conoce todos los tratamientos administrados en este estudio, su descripción detallada y en qué consisten.2 grupos de intervención están designados en este estudio
50% de probabilidad de ser asignado al grupo placebo
Grupos de Tratamiento
Grupo I
Comparador ActivoGrupo II
SimuladoCentros del Estudio
Estos son los hospitales, clínicas o centros de investigación donde se lleva a cabo el estudio. Puedes encontrar la ubicación más cercana a ti y su estado de reclutamiento.Este estudio tiene una ubicación