Veverimer for Adults with CKD and Metabolic Acidosis

This study focuses on evaluating the effectiveness and safety of a treatment called veverimer in adults diagnosed with moderate-to-severe chronic kidney disease (CKD) who also have metabolic acidosis, a condition where the body produces too much acid. The goal is to understand if veverimer can help manage these conditions better, potentially improving the quality of care for those affected. During this 26-week study, participants will receive veverimer treatment. The study measures the results by observing changes in the serum bicarbonate concentration, a key indicator of acid levels in the body. Additionally, it assesses if veverimer improves physical performance using a test called the Sit-to-Stand 5 times test (STS5), which evaluates lower body strength and balance.