miR-342-5p/AnkG Pathway-Mediated Axon Initial Segment Filtering Injury and Early Synaptic Dysfunction in Alzheimer's Disease: Biomarker Exploration

Alzheimer's disease is a common condition that affects memory and cognitive abilities, particularly in older adults. The cause behind the early abnormalities in synaptic connections between brain cells in Alzheimer's is still unclear. Previous research suggests that certain substances, known as the miR-342-5p/AnkG-mediated pathway, might play a role in these abnormalities. These substances can be found in both blood and cerebrospinal fluid. This study aims to delve deeper into understanding the specific mechanisms behind these abnormal connections. The goal is to identify biomarkers for early detection of Alzheimer's, which could potentially pave the way for improved diagnosis in the future.