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Comparación de Tratamientos para Piojos: Lotion Verde Elimax vs Champú para Piojos de Walgreens

0 criterios cumplidosConsulta de un vistazo cómo tu perfil cumple con cada criterio de elegibilidad.
Qué se está evaluando

Elimax Green Lotion with Emogreen

+ Walgreens Lice Killing Shampoo
Dispositivo
Medicamento
Quiénes están siendo reclutados

A partir de 6 meses
Ver todos los criterios de elegibilidad
Cómo está diseñado el estudio

Estudio de Tratamiento

Intervencional
Inicio del estudio: octubre de 2025
Ver detalles del protocolo

Resumen

Patrocinador PrincipalOystershell NV
Última actualización: 11 de diciembre de 2025
Extraido de una base de datos validada por el gobierno.Reclamar como socio
Fecha de inicio: 2 de octubre de 2025Fecha en la que se inscribió al primer participante.

Este estudio se centra en comparar dos tratamientos para las infestaciones de piojos de la cabeza: la Lotion Verde Elimax con Emogreen y el Champú Antipiojos de Walgreens. Los piojos de la cabeza son un problema común que afecta a personas de todas las edades, especialmente a los niños. El estudio tiene como objetivo determinar cuál producto es más efectivo y seguro para tratar los piojos de la cabeza. La Lotion Verde Elimax actúa asfixiando y deshidratando físicamente los piojos y sus huevos a través de sus ingredientes, que incluyen un bio-alcano y cera de abeja. Esta investigación es importante porque podría proporcionar una solución más efectiva para quienes sufren de piojos de la cabeza, mejorando el confort y reduciendo el tiempo dedicado al tratamiento de las infestaciones. Los participantes en este estudio deben tener seis meses de edad o más y tener un caso confirmado de piojos de la cabeza. El estudio seguirá las directrices para ensayos clínicos de dispositivos médicos según las regulaciones de EE. UU. Los participantes utilizarán el producto según las instrucciones, lo que generalmente implica aplicar el tratamiento y usar un peine para piojos. Los investigadores supervisarán la seguridad verificando cualquier irritación en la piel o los ojos y otros eventos adversos. El objetivo es asegurar que el producto no solo funcione de manera efectiva, sino que también sea seguro para los usuarios. Al comparar los resultados de estos dos tratamientos, el estudio busca ofrecer una mejor orientación para las personas que lidian con los piojos de la cabeza.

Título OficialIn Vivo Testing: A Two-Arm, Randomized, Controlled, Investigator/Assessor-Blinded, Comparative Study to Evaluate the Safety and Efficacy of a Head Lice Physically Acting Product: ELIMAX GREEN LOTION EMOGREEN (X92001752) vs Walgreens Lice Killing Shampoo (Piperonyl Butoxide (4%),Pyrethrum Extract (Equivalent to 0.33% Pyrethrins)) in Subjects With Head Lice. 
NCT07191457
Patrocinador PrincipalOystershell NV
Última actualización: 11 de diciembre de 2025
Extraido de una base de datos validada por el gobierno.Reclamar como socio

Protocolo

Esta sección proporciona detalles del plan del estudio, incluyendo cómo está diseñado y qué se está evaluando.
Detalles del Diseño
Se reclutarán 86 pacientesNúmero total de participantes que el ensayo clínico espera reclutar.
Estudio de Tratamiento
Estos estudios prueban nuevas formas de tratar una enfermedad, condición o problema de salud. El objetivo es determinar si un nuevo medicamento, terapia o enfoque funciona mejor o tiene menos efectos secundarios que las opciones existentes.

Cómo se asignan los participantes a diferentes grupos/brazos
En este estudio clínico, los participantes se colocan en grupos de forma aleatoria, como si se lanzara una moneda. Esto garantiza que el estudio sea justo e imparcial, lo que hace que los resultados sean más confiables. Al asignar a los participantes al azar, los investigadores pueden comparar mejor los tratamientos sin influencias externas.

Otras formas de asignar participantes
Asignación no aleatoria
: Los participantes se asignan en función de factores específicos, como su condición médica o la decisión de un médico.

Ninguna (ensayo de un solo brazo)
: Si el estudio tiene un solo grupo, todos los participantes reciben el mismo tratamiento y no se necesita asignación.

Cómo se administran los tratamientos a los participantes
Los participantes se dividen en diferentes grupos, y cada uno recibe un tratamiento específico al mismo tiempo. Esto ayuda a los investigadores a comparar la eficacia de los distintos tratamientos entre sí.

Otras formas de asignar tratamientos
Asignación a un solo grupo
: Todos reciben el mismo tratamiento.

Asignación cruzada
: Los participantes cambian de tratamiento durante el estudio.

Asignación factorial
: Los participantes reciben diferentes combinaciones de tratamientos.

Asignación secuencial
: Los participantes reciben tratamientos uno tras otro en un orden específico, posiblemente según su respuesta individual.

Otra asignación
: La asignación de tratamientos no sigue un diseño estándar o predefinido.

Cómo se controla la efectividad del tratamiento
En un estudio no controlado con placebo, ningún participante recibe una sustancia inerte (placebo) para comparar los resultados. En su lugar, todos los participantes reciben el tratamiento experimental o una alternativa activa (a menudo el tratamiento estándar). Este método permite comparar los efectos del tratamiento experimental con los de otra intervención activa, en lugar de un placebo.

Otras opciones
Controlado con placebo
: Se utiliza un placebo para comparar los efectos del tratamiento experimental con los de una sustancia inerte, aislando así el efecto real del tratamiento.

Cómo se mantiene la confidencialidad de las intervenciones asignadas a los participantes
Participantes, investigadores y evaluadores de resultados no saben qué tratamiento se está administrando. Esto ayuda a reducir el sesgo tanto durante el estudio como al momento de analizar los resultados.

Otras formas de enmascarar la información
Abierto
: Todos saben qué tratamiento se está administrando.

Simple ciego
: Los participantes no saben qué tratamiento están recibiendo, pero los investigadores sí.

Doble ciego
: Ni los participantes ni los investigadores saben qué tratamiento se está administrando.

Cuádruple ciego
: Participantes, investigadores, evaluadores de resultados y personal de atención no saben qué tratamiento se está administrando.

Elegibilidad

Los investigadores buscan pacientes que cumplan ciertos criterios, conocidos como criterios de elegibilidad: estado general de salud o tratamientos previos.
Criterios
Cualquier sexoSexo biológico de los participantes elegibles para inscribirse.
A partir de 6 mesesRango de edades de los participantes que pueden unirse al estudio.
Voluntarios sanos no permitidosIndica si personas sanas, sin la condición que se estudia, pueden participar.
Criterios

Inclusion Criteria: * Gender: male / female. * Female subjects with childbearing potential who test negative for pregnancy and agree to use a reliable method of birth control (as described in section7.8) or remain * Age ≥ 6 months of age at the time of enrollment. * Subject must have an active head lice infestation defined as at least 5 live lice (adults and/or nymphs) and 5 live nits based on magnified observations, present on the scalp and/or hair, as determined by a trained evaluator. * Subject is in good general health based on medical history. * Following application per designated product timeline shampoo hair using Johnson's baby shampoo (See figure 4 for shampoo image) to rinse out the product according to the study product its IFU. Subject agrees not to additionally shampoo, wash, or rinse their hair or scalp for 24-hours post treatment. * The subject agrees not to cut or chemically treat their hair while participating in the study. * Subject agrees to follow all study instructions, including attending all follow-up appointments. * Agree to not use any other anti-lice treatment or medicated hair grooming products for the duration of the study (through Day 10 visit). * The parent or legal guardian of a child must be willing to have other family members screened for head lice. If other household members are found to have head lice and are eligible, they must be either enrolled in the study OR receive the standard of care at the site and in the same manner as study participants. * Have a single place of residence or agree to remain at the current residence for the duration of the study. * The subject or his/her parent/legal guardian (from age 12-17), must give written informed consent, after having been informed orally and by written text about the benefits and potential risks of the trial, as well as information regarding the insurance, taken out to cover the subjects participating in the study. A caregiver must sign an informed consent agreement for children not old enough to do so. Children aged 6-11 years of age will be administered a child's assent form. Subject or his/her parent/legal guardian must be capable of understanding and providing written informed consent. Exclusion Criteria: * Application of any form of head lice treatment, whether prescription or over-thecounter (OTC), or home remedy for 14 days prior to their screening visit (Visit * Application of any topical medication of any kind on the hair or scalp for a period of 48 hours prior to the screening visit. * Use of systemic or topical drugs or medications, including systemic antibiotics, which in the opinion of the investigative personnel may interfere with the study results. * Known skin allergies, multiple drug allergies or multiple allergies to cosmetic products. * History of allergy or hypersensitivity to active ingredients, or constituents of the test products. * Subject with any visible skin/scalp condition at the treatment site which, in the opinion of the investigative personnel, will interfere with the evaluation of the test product. * Subjects with chronic scalp disorder. * Subject or his/her legal guardian who, in the opinion of the investigative personnel, do not understand the subject requirements for study participations and/or may be likely to exhibit poor compliance with the required visits. * Females who are pregnant or nursing. * Hair longer than waist length. * Subject suspected or known not to follow instructions * Previous participation in this study or participation in any other investigational trial within the preceding 14 days. * The subject is directly affiliated to the investigator site personnel and/or their immediate families. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted. * The subject is an Oystershell employee or is an employee of a third-party organizations involved in the study. * Exclude families with 4 or more household members. * People with dreadlocks or clip in hair that cannot be removed or a person who does not want to remove these. * Hair that is too difficult to work with, assessed by the study staff. * Families excluded where lice exist however family member declines enrollment in the study. * Subjects who are receiving, or are expected to receive, any antibiotic therapy during the study period will be excluded. * No more than one working subject per household may be excluded from evaluation if he is assessed as being lice by himself or caregiver. Only working male can be excluded from evaluation if individual is bald or hair no longer than half inch and deemed lice free by himself or another adult. * All household members of the subject, other than excluded male adult, must be screened for head lice by a licenced head lice professional. If additional household members are found to have head lice and meet the study criteria, they will be referred to LSRN Research and enrolled in study. If a household member declines enrollment, all family members will be excluded from the study.


Plan de Estudio

Conoce todos los tratamientos administrados en este estudio, su descripción detallada y en qué consisten.
Grupos de Tratamiento
Objetivos del Estudio
2 grupos de intervención 

están designados en este estudio

0% de probabilidad 

de ser asignado al grupo placebo

Grupos de Tratamiento
Grupo I
Experimental
Lice treatment with Elimax Green Lotion (Emogreen)

STEP 1: Apply the lotion to dry hair, completely saturating hair and scalp. Use a towel to cover eyes and exposed skin areas. Massage from the roots to the tips, paying particular attention to the area behind the ears and the hairline at the back of the head. Leave the lotion in the hair for 10 minutes (no longer). In the case of long hair, pin the hair up away from the skin after application. STEP 2: Wash out by applying shampoo to the hair and rinsing thoroughly. Repeat if needed to fully rinse out the lotion. STEP 3: Comb to remove lice and nits. Part the hair into sections and comb one section at a time. Place the teeth of the comb as close as possible to the scalp and comb away from the scalp to the end of the hair. Use clips to pin back each section of combed hair. Clean the comb during use by wiping onto a tissue. Discard the tissue into a sealable bag. Discard the sealed bag. Check hair for the following 7 to 10 days. If lice or nits are present, repeat steps 1-3.
Grupo II
Comparador Activo
Topical lice treatment with Walgreens Lice Killing Shampoo

Apply thoroughly to dry hair or other affected area. For head lice, first apply behind ears and to back of neck Allow product to remain for 10 minutes, but no longer Use warm water to form a lather, shampoo, then thoroughly rinse For head lice, towel dry hair and comb out tangles Remove lice and their eggs (nits) Use a fine-tooth or special lice/nit comb. Remove any remaining nits by hand (using a throw-away glove) Hair should remain slightly damp while removing nits If hair dries during combing, dampen slightly with water For head lice, part hair into sections. Do one section at a time starting at the top of the head. Longer hair may take 1 to 2 hours. Lift a 1- to 2- inch wide strand of the hair. Place comb as close as possible to the scalp and comb with a firm, even motion away from the scalp. Pin back each strand of the hair after combing Clean comb often. Wipe away nits with tissue and discard in a plastic bag. Seal bag and discard bag to prevent lice from coming back.
Objetivos del Estudio
Objetivos Primarios

Demonstrate that local application of Elimax Green Lotion with Emogreen achieves a cure rate that is non-inferior to Wallgreens Lice Killings Shampoo, at the end of day 10, corrected for re-infestation. A non-inferiority margin of 3% will be applied. If non-inferiority is established, a subsequent test will be conducted to assess whether the test product is superior to the reference product. This implies that the lower bound of the confidence interval for the difference in cure rates lies above zero.
Objetivos Secundarios

Determine efficacy of the investigational product for head lice for mild and moderate baseline infestations (cure rate at the end of the study day 10, uncorrected as well as corrected for re-infestation).

Determine efficacy of the investigational product for all baseline infestations (cure rate at day 1).

Determine efficacy of the investigational product for mild and moderate baseline infestations (cure rate at day 1).

To evaluate local tolerability by subject: subjective symptoms (burning, paraesthesia, pruritus): 0h, 1h, 24h, 7d and 10d p.a. (descriptive evaluation). The following 4-category scale will be used: * Score 1 - None: No sensation reported. * Score 2 - Mild: Slight, brief sensation (e.g. tingling or slight itch) easily tolerated and does not interfere with daily activities. * Score 3 - Moderate: Apparent discomfort (e.g. burning sensation, moderate itching) that may periodically distract or cause a minor disruption but does not require any treatment. * Score 4 - Severe: Prolonged or intense sensation (e.g. strong burning and/or itching) that interferes with normal activities or requires an intervention (e.g. cold compress, medication).

Global tolerability (general well-being and global tolerability of the test product) will be assessed by the blinded study staff at day 10. The global tolerability will be rated on a 4-category scale with: Score 1 = very good, Score 2 = good, Score 3 = moderate, Score 4 = poor. Evaluation at 10d after application.

To evaluate skin irritation by study staff (secondary infection, erythema, excoriation) on day 0, 1, 7 and 10. The following 4-category scale will be used: * Score 1 - None: No visible skin reaction. * Score 2 - Mild: Slight redness or dryness; with no swelling, peeling, or open sores; does not interfere with daily activities. * Score 3 - Moderate: Pronounced erythema, itching, or localized excoriation; may be associated with discomfort or require a non-prescription topical treatment. * Score 4 - Severe: Intense noticeable redness, edema, raw and/or broken skin (e.g. breakdown of skin with oozing or bleeding); may require medical intervention or lead to the discontinuation of the investigational product

To evaluate eye irritation by study staff on day 0, 1, 7 and 10. The following 4-category scale will be used: * Score 1 - None: No redness or irritation; the eyes appear normal. * Score 2 - Mild: Slight conjunctival redness or dryness; with no tearing or discomfort. * Score 3 - Moderate: Noticeable redness with possible tearing or discomfort; does not impair vision or require any treatment. * Score 4 - Severe: Apparent redness with significant irritation, tearing, or pain; possibly interferes with vision or requires medical treatment.

To evaluate characterization of safety and tolerability of the investigational product considering adverse events in the study population.

The esthetical properties of the investigational products will be evaluated to determine the satisfaction by the subjects with the products after application using a questionnaire about hair and scalp feeling, greasiness, hair look, shininess, and volume. With each question being scored on a scale from 1-4: * Score 1 = Strongly agree * Score 2 = Agree * Score 3 = Disagree * Score 4 = Strongly disagree

Centros del Estudio

Estos son los hospitales, clínicas o centros de investigación donde se lleva a cabo el estudio. Puedes encontrar la ubicación más cercana a ti y su estado de reclutamiento.
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LSRN ResearchEnid, United StatesVer ubicación

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