Crema de Delgocitinib para la Pustulosis Palmoplantar en Adultos

Delgocitinib cream

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Number of Participants Achieving at Least 75% Improvement in PPP Area and Severity Index (PPPASI) Score from Baseline (PPPASI-75) at Week 16

Change from Baseline to Week 16 in PPP-SA Pain Score for the Feet

Change in Fresh Pustules at Weeks 1, 2, 4, 8, and 12

Number of Fresh Pustules Overall at Weeks 1, 2, 4, 8, 12, and 16

Number of Participants Achieving PPPASI-90 at Week 16

Change from Baseline to Week 16 in PPP-symptoms assessment (SA) Score

Percentage Change in PPP-SA Score from Baseline to Week 16

Change from Baseline to Week 16 in PPP-SA Itch Score for the Hands

Change from Baseline to Week 16 in PPP-SA Itch Score for the Feet

Change from Baseline to Week 16 in PPP-SA Pain Score for the Hands

Number of Participants with PPP-Physician Global Assessment (PGA) Score of 0 or 1 with at Least a 2-step Improvement from Baseline at Week 16

Change in the Overall Number of Fresh Pustules From Baseline to Week 16

Number of Participants with a ≥1-point Reduction in PPP-PGA Score From Baseline to Week 16

Number of Participants with a ≥2-point Reduction in PPP-PGA Score From Baseline to Week 16

Change in PPPASI Score From Baseline to Week 16

Percentage Change in PPPASI Score From Baseline to Week 16

Number of Participants Achieving PPPASI-50 at Week 16

Number of Participants who Experienced Treatment-emergent Adverse Events (TEAEs)

Number of Participants with a ≥4-point Reduction in Dermatology Life Quality Index (DQLI) Score From Baseline to Week 16

Change from Baseline to Week 16 in DLQI Score

Percentage Change from Baseline to Week 16 in DLQI Score

Change from Baseline to Week 16 in PPP-Impact Assessment (IA) Score

Percentage Change from Baseline to Week 16 in PPP-IA Score

Change in Work Productivity and Activity (WPAI) PPP Absenteeism Score from Baseline to Week 16

Change in Work WPAI:PPP Presenteeism Score from Baseline to Week 16

Change in WPAI:PPP work Productivity Score from Baseline to Week 16

Change in WPAI:PPP Activity Impairment Score from Baseline to Week 16