Impacto del Alopurinol en el Metabolismo Mineral y Óseo en Pacientes con Enfermedad Renal Crónica

This study focuses on understanding the impact of a medication called Allopurinol on bone and mineral health in patients with Chronic Kidney Disease (CKD). The research takes place in Sao Paulo, Brazil, and involves patients in stages 3, 4, or 5 of CKD who are under conservative management at the Nephrology Service of Hospital das Clinicas HCFMUSP. The study aims to find out if Allopurinol can improve bone health and mineral balance in these patients, which could lead to better care and quality of life for individuals living with CKD. During the study, patients receive either Allopurinol or a placebo (a pill with no active ingredients) for 3 months. The effects of these treatments on bone health and mineral balance are measured through changes in specific substances in the body, such as 1,25 dihydroxivitamin D, FGF-23, and alpha Klotho. Patients are monitored by the same physician throughout the study, and any adverse effects are recorded.