NICOVIDEvaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Hospitalized Patients

Fecha de inicio: 9 de diciembre de 2020

Inclusion Criteria: * Age ≥ 18 years * Patients hospitalized for less than 72 hours * Non-smoking and non-vaping patients (for former smokers or former vapers: abstinent for at least 12 months) * Documented diagnosis of COVID19 * Lung disease suggestive of COVID-19 on chest scanner or need for oxygen therapy * Obtaining, informed and signed consent * Affiliated to a social security scheme or beneficiary of such a scheme (except AME) Exclusion Criteria: * WHO 10-point Clinical Progression Scale score \> 5 (patient on non-invasive or mechanical ventilation, patient in need of high-flow oxygen therapy) * Indication of transfer to intensive care unit (oxygen therapy\> 8 L / min ; out or not carried out due to LATA) * Current treatment with nicotine replacement therapy, bupropion or varenicline in the last 30 days * Known addiction problem to alcohol or other substances * Contraindication for nicotine patches: * pregnant or breastfeeding woman * lack of effective contraception for women of childbearing age * Generalized skin pathologies that may interfere with the use of a transdermal patch * stroke or myocardial infarction or acute coronary syndrome for less than 3 months * allergy to nicotine or to one of the excipients of the transdermal patch * Uncontrolled high blood pressure * Unstable or worsening angina * Severe cardiac arrhythmia (defined by wearing an automatic implantable defibrillator) * Known obliterating peripheral arterial disease * Known severe heart failure with an ejection fraction \<30%) * Known severe renal (ClCr \<30 ml / min) or hepatic (Child C) impairment * Known pheochromocytoma * Known uncontrolled hyperthyroidism * Esophagitis due to gastroesophageal reflux disease or an active peptic ulcer * Patient included in another interventional trial evaluating a health product * Patient under guardianship or curatorship * Patient deprived of liberty by judicial or administrative decision