BulleEchoLung Ultrasound Characterization of Bullous Emphysema
Colección de datos
Recopilados desde hoy en adelante - ProspectivoEnfermedad Crónica+4
+ Enfermedades del pulmón
+ Enfermedades Pulmonares Obstructivas
Casos y Controles
Examen de las características de personas con una enfermedad para identificar factores genéticos o ambientales que contribuyen a la condición.Resumen
Fecha de inicio: 26 de junio de 2019
Fecha en la que se inscribió al primer participante.Chronic Obstructive Pulmonary Disease (COPD) is a frequent disease affecting a growing number of adults in the world which is responsible for a large public health burden through heavy morbidity and mortality. Emphysema is one of a wide spectrum of pulmonary complications linked to COPD, defined as the abnormal permanent enlargement of the airspaces distal to the terminal bronchioles accompanied by destruction of the alveolar wall. Disease progression is correlated to worsening and enlargement of emphysema lesions, sometimes conflating in sizeable bullae, deleterious to normal mechanical pulmonary function. Bullous emphysema (BE) is sometimes eligible to invasive curative treatment through surgery or interventional bronchoscopy. Diagnosis of BE relies on computerized tomodensitometry (CT), the gold-standard for evaluating pulmonary parenchyma. However, CT is not always available, and bullous emphysema can present as pneumothorax on chest radiography. The practice of lung ultrasound is currently growing in respiratory medicine and emergency departments owing to an increasing amount of evidence showcasing its reliability as a diagnostic tool, most notably for pneumothorax and other pleural diseases. Despite BE having been reported to present similarly to pneumothorax in ultrasound, its characteristics have not yet been precisely described. The primary aim of this study is to describe BE using lung ultrasound. Participants with known BE on CT will undergo a simple ultrasound examination. The secondary aim is to compare the characteristics of BE to those of pneumothorax using lung ultrasound. To achieve this, a second group of participants with currently treated pneumothorax will also undergo lung ultrasound.
Protocolo
Esta sección proporciona detalles del plan del estudio, incluyendo cómo está diseñado y qué se está evaluando.Se reclutarán 35 pacientes
Número total de participantes que el ensayo clínico espera reclutar.Casos y Controles
Elegibilidad
Los investigadores buscan pacientes que cumplan ciertos criterios, conocidos como criterios de elegibilidad: estado general de salud o tratamientos previos.Cualquier sexo
Sexo biológico de los participantes elegibles para inscribirse.A partir de 18 años
Rango de edades de los participantes que pueden unirse al estudio.Voluntarios sanos no permitidos
Indica si personas sanas, sin la condición que se estudia, pueden participar.Condiciones
Patología
Criterios
Inclusion Criteria: * Bullous emphysema group * Consultation or scheduled hospitalization in a Pulmonary Medicine department * Past medical history of emphysema on computerized tomodensitometry dating less than two years * Bullous emphysema with subpleural contact of two or more intercostal spaces on tomodensitometry * Pneumothorax group * Hospitalized in a Pulmonary Medicine department for the treatment of a pneumothorax * Patent pneumothorax visible on chest x-ray dating less than 24 hours Exclusion Criteria: * Bullous emphysema group * Current pneumothorax * Past medical history of pleurodesis or pleural thickening homolateral to the bullous emphysema * All patients * Organ failure (hemodynamic, neurological, respiratory) * Recent thoracic surgery dating less than 7 days with subcutaneous emphysema * Minor participant or otherwise deprived of their freedom or their ability to consent freely * No affiliation to social security
Plan de Estudio
Conoce todos los tratamientos administrados en este estudio, su descripción detallada y en qué consisten.Objetivos del Estudio
Objetivos Primarios
Objetivos Secundarios
Centros del Estudio
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Pulmonary Medicine, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital
Rouen, FranceAbrir Pulmonary Medicine, Thoracic Oncology and Respiratory Intensive Care Department, Rouen University Hospital en Google Maps