MICROTONEViral and Microbial Circulation Between Humans, Domesticated and Wild Animals Along an Ecotone, Democratic Republic of Congo
blood sampling
+ stool collection
+ Participatory activity and contact investigation
Enfermedades de los Animales
+ Infecciones
+ Zoonosis
Estudio de Ciencia Básica
Resumen
Fecha de inicio: 15 de marzo de 2019
Fecha en la que se inscribió al primer participante.The MICROTONE study sheds light on zoonotic disease emergence by examining social and ecological pathways facilitating microbial and viral flows between people and selected wild and domesticated animals along a gradient of ecological change in a forest-savanna mosaic in the Democratic Republic of Congo, an epicenter of zoonotic disease emergence. The investigators analyze potential viral and bacterial overlap among humans and animals and explain this overlap (or not) through social sciences and ecological analyses of human and animal mobilities, practices and contacts. This multi-disciplinary, multi-species investigation in an ecotone (a transitional ecological zone linked to zoonotic disease emergence) offers a "pre-history" of spillover and emergence, tracing an ecological zeb of virome and microbial sharing among humans and animals. It will elucidate why such microbial and viral flows occur. To conduct this investigation,there are two human sub-studies: the social sciences participatory study; and the clinical study. The clinical study will involve 30 human subjects from whom blood and stool samples will be collected. The social sciences participatory study will involve self-collected activity and animal contact data and oral interviews among 60 human subjects.
Protocolo
Esta sección proporciona detalles del plan del estudio, incluyendo cómo está diseñado y qué se está evaluando.Se reclutarán 60 pacientes
Número total de participantes que el ensayo clínico espera reclutar.Estudio de Ciencia Básica
Elegibilidad
Los investigadores buscan pacientes que cumplan ciertos criterios, conocidos como criterios de elegibilidad: estado general de salud o tratamientos previos.Cualquier sexo
Sexo biológico de los participantes elegibles para inscribirse.A partir de 18 años
Rango de edades de los participantes que pueden unirse al estudio.Voluntarios sanos permitidos
Indica si personas sanas, sin la condición que se estudia, pueden participar.Condiciones
Patología
Criterios
Inclusion Criteria: * Age 18 years or older * Accept participation in study * Residing in one of three villages selected * In good health and able to conduct habitual daily activities * Accept self-collection of 2g of stool * Accept blood collection (2-2.5 ml) by a medical professional * Accept to self-collect daily activities and contacts with selected wild and domesticated animals for five months * Accept to participate in an anthropological-historical interview on changing practices and contacts with wild and domesticated animals Exclusion Criteria: * Vulnerable adults will not be included * Women who are pregnant or nursing at the time of recruitment and inclusion will not be included. * Adults declaring themselves ill and unable to conduct their habitual daily activities will not be included. * Adults with a chronic illness will not be included * Adults who have a family member already included in the study will not be included. * Adults refusing either recording of interviews or note-taking during interviews will not be included.
Plan de Estudio
Conoce todos los tratamientos administrados en este estudio, su descripción detallada y en qué consisten.Un solo grupo de intervención está designado en este estudio
0% de probabilidad de ser asignado al grupo placebo
Grupos de Tratamiento
Grupo I
ExperimentalObjetivos del Estudio
Objetivos Primarios
Objetivos Secundarios
Centros del Estudio
Estos son los hospitales, clínicas o centros de investigación donde se lleva a cabo el estudio. Puedes encontrar la ubicación más cercana a ti y su estado de reclutamiento.Este estudio tiene una ubicación