A Randomized, Placebo-controlled Study Investigating the Effects of Moxaverine on Ocular Blood Flow After Oral Administration in Healthy Subjects

Fecha de inicio: 1 de octubre de 2010

Inclusion Criteria: * Men and women aged between 18 and 35 years, nonsmoker * Body mass index between 16 and 30 kg/m² * Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant * Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant * Normal ophthalmic findings, ametropia \< 6 dpt, anisometropia \< 2 dpt Exclusion Criteria: * Regular use of medication, abuse of alcoholic beverages or drugs * Participation in a clinical trial in the 3 weeks preceding the study * Treatment in the previous 3 weeks with any drug * Symptoms of a clinically relevant illness in the 3 weeks before the first study day * History or presence of gastrointestinal, liver or kidney disease, or other conditions known to interfere with distribution, metabolism or excretion of the study drug * Blood donation during the previous 3 weeks * Presence of any ocular pathology that interferes with the aims of the present study * Hypersensitivity to moxaverine * Acute gastric bleeding, massive cerebral hemorrhage related to stroke * Women: pregnancy or lactation