Cranberry Juice Impact on Antibiotic Absorption in UTI Treatment

Many people drink cranberry juice to prevent urinary tract infections (UTIs), even though its effectiveness is not fully proven. Recent findings suggest that cranberry juice might interfere with how the body processes antibiotics used for UTI treatment. This study aims to find out if drinking cranberry juice while taking two common UTI antibiotics, amoxicillin and cefaclor, reduces their concentration in the urine. The study involves children undergoing UTI treatment and adults without UTIs. Children participating in the study will continue their amoxicillin/cefaclor treatment as prescribed. After 7 to 10 days of antibiotic treatment, they will either receive cranberry juice for 2 days or no additional treatment. Urine samples will be taken from all child participants before and after giving cranberry juice to check antibiotic levels. Adult participants will receive two different doses of amoxicillin, either with or without cranberry juice. Blood and urine samples will be collected to see how cranberry juice affects the body's absorption and elimination of amoxicillin.