Objectives: to study potential structural and functional abnormalities in patients with an inherited form of epilepsy. Study Population: Patients with autosomal dominant partial epilepsy with auditory features, a newly described syndrome, asymptomatic family members who are gene carriers, and unaffected family members, and normal volunteers. Design: magnetic resonance imaging, electroencephalography, and magnetoencephalography. Outcome measures: detection of structural lesions; regional activation patterns on fMRI.
* INCLUSION CRITERIA: Patients and family members in kindreds with ADPEAF evaluated by Dr. Ruth Ottman at CPMC: 14 patients with seizures and the LGl1 mutation. 14 family members with the mutation but no seizures. 14 Non-affected family members, who are not carriers of the LGl1 mutation. 30 normal controls selected at NIH, and screened in the CES outpatient clinic with a physical and neurological examination. EXCLUSION CRITERIA: Subjects unable or unwilling to undergo MRI, EEG, and MEG. Women who are pregnant. Subjects under 18. Subjects with medical conditions other than ADPEAF that may affect brain function. Subjects taking medications or neuroactive substances that may affect brain function. Healthy volunteers must be below the age of 55, to reduce the chance of vascular chnages that could affect MRI.