Allogeneic Stem Cell Transplantation of Renal Cell Cancer and Metastatic Melanoma After Non-Myeloablative Chemotherapy

Fecha de inicio: 1 de febrero de 1999

DISEASE CHARACTERISTICS: Histologically confirmed metastatic renal cell carcinoma or melanoma that is not potentially curable by surgery Evaluable disease or bidimensionally measurable disease on physical examination, chest x-ray, CT scan, or MRI Measurable disease by radiography must be reproducible Bony disease or effusions not measurable No active CNS disease currently receiving radiotherapy or steroids No effusion or ascites of more than 1 liter prior to drainage HLA 5/6 or 6/6 matched sibling donor available No known hypersensitivity to E. coli derived products No active infection No health condition that would preclude donation PATIENT CHARACTERISTICS: Age: 18 to 65 Performance status: CALGB 0-2 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Bilirubin no greater than 2.0 g/dL No active hepatitis Renal: Creatinine no greater than 2.0 mg/dL OR Creatinine clearance greater than 50 mL/min Cardiovascular: LVEF at least 50% Pulmonary: DLCO at least 50% of predicted Other: No active infection HIV negative No psychological problem that would preclude study compliance No known hypersensitivity to E. coli derived products Not pregnant or nursing Negative pregnancy test PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: At least 4 weeks since prior systemic chemotherapy Endocrine therapy: See Disease Characteristics Radiotherapy: See Disease Characteristics At least 4 weeks since prior radiotherapy Surgery: See Disease Characteristics