Study of Abnormal Acquired and Genetic Coagulation Factors in Children With Porencephaly and Stroke

Fecha de inicio: 22 de febrero de 1999

INCLUSION CRITERIA: CHILDREN WITH A HISTORY OF PORENCEPHALY OR STROKE: Children less than 18 years of age with a history of porencephaly or cerebral infarction (stroke). Children less than 18 years of age with a history of spastic hemiplegic or quadriplegic cerebral palsy (ICD-9 codes 343.1, 343.2, 343.3, 343.4, 343.8 and 343.9) with radiographic evidence of porencephaly or stroke. A diagnosis of porencephaly as defined by a fluid-filled cavity within the cerebral hemispheres which may or may not communicate with CSF spaces and confirmed by at least one imaging method including computed tomography (CT), magnetic resonance (MR) and or Doppler ultrasonography. A diagnosis of cerebral infarction (stroke) as defined by a new focal neurologic deficit lasting greater than or equal to 24 hours and presumably due to a vascular process (ICD-9 codes 430-437) and confirmed by brain imaging, either computed tomography (CT), magnetic resonance (MR) or Doppler ultrasonography. Informed consent of the parent. Informed assent of the child, when available. FIRST-DEGREE RELATIVES OF CHILDREN WITH PORENCEPHALY OR STROKE: Full biological first-degree relatives of children with a history of porencephaly or stroke enrolled in this study. Informed consent of each participant. Informed assent of each participant under 18 years, when available. HEALTHY CHILDREN: Children less than 18 years of age. Informed consent of the parent. Informed assent of the child when available. HEALTHY MOTHERS: Women between 18 and 45 years of age. History of full-term pregnancy. Informed consent of the participant. EXCLUSION CRITERIA: CHILDREN WITH A HISTORY OF PORENCEPHALY OR STROKE: Children greater than 18 years of age. Maternal history of cocaine abuse during pregnancy. History of cancer. History of other chromosomal or metabolic disorder. History of trauma and or child abuse. Isolated subdural hematomas. History of aneurysm or vascular malformations. Congenital heart disease. Sickle cell disease. History of CNS infection. HEALTHY CHILDREN: Children greater than 18 years of age. Maternal history of cocaine abuse during pregnancy. History of cancer. History of other chromosomal or metabolic disorder. History of trauma and or child abuse. Isolated subdural hematomas. History of aneurysm or vascular malformations. Congenital heart disease. Sickle cell disease. History of CNS infection. History of stroke or porencephaly. HEALTHY MOTHERS: Volunteer has biological children without a history of cancer, head trauma, aneurysm, chromosomal or metabolic disorder, congenital heart disease, sickle cell disease, meningitis or encephalitis, or stroke. Cocaine use during pregnancy.