Phantom Pain: A Therapeutic Trial Using Transcranial Magnetic Stimulation
Colección de datos
Enfermedades del sistema nervioso+7
+ Manifestaciones Neurológicas
+ Dolor
Estudio de Tratamiento
Resumen
Fecha de inicio: 1 de diciembre de 1998
Fecha en la que se inscribió al primer participante.Phantom pain is a chronic painful condition that affects patients with amputations. Treatment for phantom pain is often disappointing. In amputees, hyperexcitability of the posterior parietal cortex area (PPC) contralateral to the side of the amputation has been linked with the presence of phantom sensations. PPC is an area overactive in different forms of chronic pain too. It is therefore conceivable that downregulation of activity in PPC could improve phantom limb pain, a condition poorly responsive to available treatments. We have previously demonstrated that low frequency TMS (1 Hz) results in decreased excitability of the stimulated cortical regions. We plan to apply low-frequency TMS to PPC cortical areas contralateral to the side of the amputated limb. We expect that this intervention will result in amelioration of the phantom pain. Stimulation of the PPC area (target intervention) will be compared with a control intervention in which TMS is directed slightly away from the head.
Protocolo
Esta sección proporciona detalles del plan del estudio, incluyendo cómo está diseñado y qué se está evaluando.Se reclutarán 20 pacientes
Número total de participantes que el ensayo clínico espera reclutar.Estudio de Tratamiento
Elegibilidad
Los investigadores buscan pacientes que cumplan ciertos criterios, conocidos como criterios de elegibilidad: estado general de salud o tratamientos previos.Cualquier sexo
Sexo biológico de los participantes elegibles para inscribirse.Voluntarios sanos no permitidos
Indica si personas sanas, sin la condición que se estudia, pueden participar.Condiciones
Patología
Criterios
Patients must be between 18 and 65 years of age. Patients must have amputations and phantom pain for at least 12 months. Patient's pain should be at least moderate and be present at least 8 hours per day or severe lasting for at least 2 hours per day. Patients must not have had a previous stroke or brain lesions. Patients must not have severe depression, poor motivational capacity. Patients must not have serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 20 or less). Patients must not have severe uncontrolled medical problems (e.g. cardiovascular disease, any kind of end-stage pulmonary or cardiovascular disease, or epilepsy). Patients must not have a personal history of seizures or other neurological disorders. Women must not be pregnant. Patients must not have severe coronary disease. Patients must not have metal in the cranium except mouth. Patients must not have intracardiac lines. Patients must not have increased intracranial pressure as evaluated by clinical means. Patients must not have cardiac pacemakers. Patients must not be taking neuroleptics.
Centros del Estudio
Estos son los hospitales, clínicas o centros de investigación donde se lleva a cabo el estudio. Puedes encontrar la ubicación más cercana a ti y su estado de reclutamiento.Este estudio tiene una ubicación
National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, United StatesAbrir National Institute of Neurological Disorders and Stroke (NINDS) en Google Maps