The Effect of Therapy on the Tissue Burden of Disseminated MAC Infection as Measured by Quantitative Bone Marrow Culture and Correlation With Quantitative Blood Culture in HIV-Infected Patients

Inclusion Criteria Concurrent Medication: Allowed: Any antiretroviral therapy that is approved or is available through an FDA-sanctioned treatment IND or treatment protocol. Primary or secondary PCP prophylaxis with TMP/SMX, dapsone, or aerosolized pentamidine, as well as approved therapies for other AIDS-related opportunistic infections not otherwise excluded. Erythromycin, interferon-alpha, and supportive care for any therapy-related toxicities as necessary. Patients must have: HIV infection. Confirmed MAC bacteremia. Consent of parent or guardian if less than 18 years of age. Exclusion Criteria Concurrent Medication: Excluded: MAC inhibitors, including aminoglycosides, quinolones, clofazimine, azithromycin (except when administered as a substitute drug), and rifamycins, during the first 24 weeks of the study. Immunomodulators (including colony-stimulating cytokines such as GM-CSF and G-CSF) other than those that are specifically allowed. Steroids in excess of physiologic replacement doses. Cytotoxic chemotherapy. Patients with the following prior conditions are excluded: History of treatment-limiting intolerance or hypersensitivity to the study drugs or other macrolides. Changes on chest radiograph within 7 days prior to study entry, that are consistent with acute Pneumocystis carinii pneumonia, pulmonary tuberculosis, or other acute respiratory infection. Prior Medication: Excluded: Clarithromycin, azithromycin, or ethambutol for more than 10 consecutive days within the 8 weeks prior to study entry OR between the time an initial AFB positive blood sample was collected and study entry. Cytokines (other than erythropoietin and interferon-alpha) within 8 weeks prior to study entry. Steroids within 8 weeks prior to study entry. Cytotoxic chemotherapy within 8 weeks prior to study entry. Acute therapy for an AIDS-related opportunistic infection or malignancy, or other acute medical illness or infection within 4 weeks prior to study entry. Rifabutin monotherapy if initiated for MAC prophylaxis between the time an initial AFB positive blood sample was collected and study entry. Aminoglycosides, quinolones, clofazimine, or rifamycins IF ADMINISTERED IN ANY COMBINATION within 7 days prior to study entry OR between the time an initial AFB positive blood sample was collected and study entry.