A Phase I/II Trial of Parenteral Pentamidine for PCP Prophylaxis in HIV-Infected Children Who Are Intolerant to Oral Trimethoprim-Sulfamethoxazole

Inclusion Criteria Concurrent Medication: Allowed: * Steroids and intravenous immune globulin (IVIG). Patients must have: * Documented HIV infection. * Need for PCP prophylaxis. * Known intolerance to trimethoprim - sulfamethoxazole (TMP-SMX). One of the following required conditions: * Known intolerance or allergy to dapsone; G6PD deficiency; history of serious or life-threatening reaction to TMP-SMX; exclusion from protocol ACTG 179; election by parent not to enroll child on ACTG 179; or receiving medical care at sites not participating in ACTG 179. NOTE: * Co-enrollment in other ACTG pediatric studies is permitted. Consent of parent or guardian is required. Prior Medication: Allowed: * Prior pentamidine. Exclusion Criteria Co-existing Condition: Patients with the following symptoms and conditions are excluded: * Active PCP. * Pancreatitis defined as amylase elevation associated with an elevated lipase that is \> 2 x upper limit of normal. Prior Medication: Excluded: * TMP-SMX or dapsone within 7 days prior to study entry (toxicities to TMP-SMX or dapsone must be clearly resolving).