A Placebo-Controlled, Phase I Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant Envelope Proteins of HIV-1 gp160 and gp120 in Children >= 1 Month Old With Asymptomatic HIV Infection

Inclusion Criteria Concurrent Medication: Recommended: PCP prophylaxis. Patients must have: Documented asymptomatic HIV infection. CD4+ count as follows: 1-11 months of age must have > 2000 cells/mm3 and >= 30 percent of the total lymphocytes; 12-23 months must have > 1000 cells/mm3 and >= 20 percent of the total lymphocytes; 24 months-6 years must have > 750 cells/mm3 and >= 20 percent of the total lymphocytes; and 7 years and older must have > 500 cells/mm3 and >= 20 percent of the total lymphocytes. NOTE: Patients who received zidovudine for 3 consecutive months immediately prior to study entry may receive only high doses of vaccine. Exclusion Criteria Co-existing Condition: Patients with the following condition are excluded: Any serious acute infection. Concurrent Medication: Excluded: Anticipated steroid therapy of > 6 weeks duration. Excluded within the past 2 years: More than one serious proven bacterial infection such as sepsis, pneumonia, meningitis, bone or joint infection, abscess of an internal organ or body cavity (other than otitis media or superficial skin or mucosal abscesses) caused by Haemophilus, Streptococcus, Pneumococcus, or other pyogenic bacteria. Prior Medication: Excluded: Antiretroviral therapy or immunomodulators (e.g., IVIG) within 1 month prior to study entry (NOTE: AZT is allowed within 1 month prior to study entry if patient is entering a high-dose arm). Uninterrupted steroid therapy of > 6 weeks duration.