Chemotherapy and Azidothymidine, With or Without Radiotherapy, for High Grade Lymphoma in AIDS-Risk Group Members

Inclusion Criteria Concurrent Medication: Allowed: * Ibuprofen. * Standard antiemetic agents. * Ganciclovir therapy for sight- or life-threatening Cytomegalovirus infection. * Zidovudine and methotrexate may be resumed during ganciclovir maintenance phase. Exclusion Criteria Co-existing Condition: The following patients will be excluded from the study: * Patients with recurrent infection that may interfere with the planned protocol. * Patients with a second active tumor other than nonmelanomatous skin cancer or Kaposi's sarcoma. * Patients with stage IE primary central nervous system lymphoma. Concurrent Medication: Excluded: * Corticosteroids. * Aspirin. * Acetaminophen. * Nonsteroidal anti-inflammatory drugs, except ibuprofen. * Chemotherapy for infection associated with neutropenia. * Zidovudine (AZT) for infection associated with neutropenia. * Investigational therapies, except ganciclovir therapy for sight- or life-threatening cytomegalovirus infection. * AZT and methotrexate will be suspended during induction therapy with ganciclovir. The following patients will be excluded from the study: * Patients with recurrent infection that may interfere with the planned protocol. * Patients with a second active tumor other than nonmelanomatous skin cancer or Kaposi's sarcoma. * Patients with stage IE primary central nervous system lymphoma. Prior Medication: Excluded: * Zidovudine (AZT). * Excluded within 2 weeks of study entry: * Immunomodulating agents. * Antiretroviral therapy prior to diagnosis of lymphoma. Patients must demonstrate the following clinical and laboratory findings: * Any stage of the disease, including stage I. * Newly diagnosed, previously untreated high-grade lymphoma. * Presence of measurable tumor parameter(s). * Adequate hepatic, renal, and bone marrow function.