Buprenorphine and Naltrexone Interaction in Addiction Treatment

This study focuses on understanding the interactions between buprenorphine and naltrexone, two medications often used in addiction treatment. The research aims to help people who are transitioning from buprenorphine to naltrexone, develop a form of buprenorphine that's less likely to be misused, and improve the acceptability of naltrexone for patients. This study is important as it could lead to better treatment options and improved care for individuals dealing with addiction. During the study, participants will receive either buprenorphine, naltrexone, or a combination of both. The main outcomes being measured include drug use, opiate withdrawal symptoms, and opioid agonist effects. Additionally, the study will monitor psychological changes such as pupil diameter, blood pressure, heart rate, and respiration. These measurements will help researchers understand how these medications interact and impact individuals, potentially leading to improved treatment strategies.