Whole Body Hyperthermia for Rheumatoid Diseases Treatment

This study focuses on using whole body hyperthermia (WBH), a non-toxic heating system, to treat rheumatoid diseases. The system, previously used at the University of Wisconsin, heats patients to a specific temperature for a set time. Researchers believe this could help with rheumatoid diseases, as it has been shown to trigger the production of certain proteins, known as soluble tumor necrosis factor-receptors (sTNF-R) I and II. These proteins could potentially improve conditions for patients with active rheumatoid arthritis, making this study significant in exploring new treatment options for these diseases. The study aims to help those with active rheumatoid arthritis, a condition that currently lacks a definitive cure. During the study, participants undergo the WBH treatment, which involves heating their bodies to 41.8 degrees Celsius for 60 minutes. The study evaluates how this treatment affects various biological markers, including cytokine levels, TNF levels, sTNF-R levels, and changes in cellular TNF receptors. The goal is to see if these changes could lead to remission in patients with active rheumatoid arthritis. The study also considers potential risks and benefits associated with the WBH treatment.