Impact of Functional Cure of Chronic Hepatitis B on Patient-Reported Outcomes

This study focuses on understanding the impact of a 'functional cure' for chronic hepatitis B on patients' quality of life and perceived stigma. It involves individuals from the 'Everest Project' cohort, who are divided into four groups: those who have achieved a clinical cure, those who have not, those who have experienced a relapse, and healthy individuals as a control group. The aim is to provide a comprehensive understanding of the psychological and social benefits of a clinical cure for hepatitis B, which could help in shifting the focus from a purely medical approach to a more holistic health model. This could also provide valuable insights for improving patient care and formulating public health policies to reduce stigma associated with the condition. Participants in this study will complete questionnaires, both online and offline, using internationally recognized scales. The primary outcome measured is the total score on the Hepatitis B Virus Infection-Related Stigma Scale (HBVISS). This scale quantifies the social and psychological stigma perceived by participants. The scores will be compared across three groups: those who have achieved a clinical cure, those who have not, and those who have experienced a relapse. A higher score indicates a greater perceived stigma.