Impact of Repeated Ischemic Preconditioning on Hemodynamic and Metabolic Parameters in Chronic Kidney Disease Patients

This study focuses on understanding how repeated episodes of a process called 'ischemic preconditioning' affect blood pressure, heart rate, and inflammation markers in individuals with various stages of kidney disease. Ischemic preconditioning involves intentionally creating brief periods of reduced blood flow to potentially protect the heart and blood vessels from future damage. This research is important as it could help develop new strategies to prevent complications in people with kidney disease. The study takes place over four days during a hospital stay in the Department of Nephrology, Hypertension, Transplantology and Internal Diseases. During the study, participants will have their blood pressure and heart rate monitored, and a small amount of blood will be taken for laboratory tests. The ischemic preconditioning process involves applying pressure to the lower leg using a blood pressure cuff for four cycles of 5 minutes each. This procedure will be repeated over the next two days. On the final day, blood pressure, heart rate, and blood saturation will be measured again, and another blood sample will be taken for comparison. The study will assess changes in specific markers such as SIRT-1, IL-6, blood saturation, blood pressure, and heart rate, from the beginning to the end of the seven-day period.