Recruiting

PRF and Corticosteroid Treatment Effects in Impacted Third Molar Surgery

Study Aim

This study aims to evaluate the effects of PRF and corticosteroid treatment on postoperative pain, swelling, and trismus in individuals undergoing impacted third molar surgery.

What is being tested

Postoperative Amoxicillin/Clavulanic Acid

+ Post-Surgery Pain Control with Paracetamol

+ Using Chlorhexidine Mouthwash After Surgery

DrugBiological

Who is being recruted

Nervous System Diseases+8

+ Neurologic Manifestations

+ Pain

Over 18 Years

+12 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Treatment Study

Interventional

Study Start: September 2024

See protocol details

Summary

Principal SponsorFinal International University

Study ContactMeliz Kneebone, DDSMore contacts

Last updated: August 3, 2026

Sourced from a government-validated database.Claim as a partner

Study start date: September 3, 2024

Actual date on which the first participant was enrolled.

This study focuses on comparing the effects of different treatments after surgery to remove impacted wisdom teeth. Specifically, it looks at the standard treatment, a treatment called platelet-rich fibrin (PRF), and a combination of PRF with corticosteroid treatment. The goal is to find out which of these treatments works best in reducing pain, swelling, and difficulty in opening the mouth after surgery. A total of 60 participants undergoing wisdom tooth removal will take part in this study, each receiving one of the three treatments. The results of this study could help improve care for people undergoing this common dental procedure. Participants in this study will have their pain, facial swelling, and mouth opening ability checked on the first, second, third, and seventh day after surgery. Pain will be measured using a scale where 0 means no pain and 10 means the worst pain imaginable. Swelling will be checked using a flexible measuring tape around specific areas of the face. Mouth opening will be assessed by measuring the distance between the upper and lower front teeth using a digital tool. This study will provide valuable insights into the effectiveness of these treatments in managing post-surgery complications.

NCT07742826

Principal SponsorFinal International University

Study ContactMeliz Kneebone, DDSMore contacts

Last updated: August 3, 2026

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

60 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Nervous System DiseasesNeurologic ManifestationsPainPathologic ProcessesSigns and SymptomsSpasmPathological Conditions, Signs and SymptomsNeuromuscular ManifestationsPain, PostoperativePostoperative ComplicationsTrismus

Criteria

4 inclusion criteria required to participate

Patients aged 18 years and older

Patients willing and able to attend all postoperative follow-up visits

Patients with complete clinical and radiographic examination (panoramic radiograph/CBCT if applicable)

Patients with good general health

8 exclusion criteria prevent from participating

Patients unable or unwilling to comply with the study protocol or attend follow-up visits

Patients using corticosteroids, anticoagulants, immunosuppressive drugs, or bisphosphonates

Patients with a history of allergy or contraindication to corticosteroids, local anesthetics, or prescribed medications

Patients with acute infection, abscess, or pericoronitis at the surgical site

Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

3 intervention groups are designated in this study

This study does not include a placebo group

Treatment Groups

Group I

Active Comparator

This group receives regular care after impacted wisdom tooth removal, including medicines Amoxicillin/Clavulanic Acid (Augmentin) and Paracetamol, and a mouthwash called Chlorhexidine. No additional treatments like platelet-rich fibrin (PRF) or corticosteroids are given.

Group II

Experimental

Participants in this group receive a special treatment called Platelet-Rich Fibrin (PRF) in the surgery area, along with standard after-surgery care including Amoxicillin/Clavulanic Acid (Augmentin), Paracetamol, and Chlorhexidine mouthwash.

Group III

Experimental

This group receives a combination of Platelet-Rich Fibrin (PRF) and a corticosteroid, along with standard post-surgery care including Amoxicillin/Clavulanic Acid (Augmentin), Paracetamol, and Chlorhexidine mouthwash.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Recruiting

Final International University Faculty of Dentistry

Nicosia, CyprusOpen Final International University Faculty of Dentistry in Google Maps

Recruiting

One Study Center