Completed

Evaluating Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer Use in Patients With Dry Skin

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What is being tested

virgin coconut oil

+ virgin jojoba oil

+ virgin almond oil

Other
Who is being recruted

Dermatitis+2

+ Eczema

+ Skin Diseases

Over 18 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: March 2017
See protocol details

Summary

Principal SponsorUniversity of Arizona
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: March 27, 2017

Actual date on which the first participant was enrolled.

This study aims to understand how different moisturizers affect dry skin. The moisturizers being tested are white petrolatum, coconut oil, jojoba oil, and almond oil. The study involves individuals with dry skin who attend Banner-University Medical Center/University of Arizona dermatology clinics and University of California, Davis dermatology clinics. By comparing the effects of these moisturizers, the study hopes to improve care for people dealing with dry skin conditions. Participants in this study will apply the four moisturizers to different areas on their forearms. The study consists of three sessions: the first at the start, and then approximately one and two weeks later. At each visit, a trained observer will assess the severity of dry skin using a validated Dry Skin Score. They will also measure skin barrier properties, such as water loss and hydration, and take digital photos of the areas for further analysis. This will help determine the effectiveness of each moisturizer in improving skin appearance and hydration.

Official TitleEvaluating Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer Use in Patients With Dry Skin
NCT03093597
Principal SponsorUniversity of Arizona
Last updated: January 27, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

37 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.


Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Over 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

DermatitisEczemaSkin DiseasesSkin and Connective Tissue DiseasesSkin Diseases, Eczematous

Criteria

Inclusion Criteria: 1. Male and female, at least 18 years of age 2. Subject must receive a diagnosis of dry skin by a dermatologist. 3. Subject must be able to comprehend and read the English language. Exclusion Criteria: 1. Subjects who do not fit the inclusion criteria. 2. Subjects unable to or unwilling to comply with the study procedures 3. Prior known allergy to white petrolatum, coconut oil, almond oil, or jojoba oil. 4. People who have used products containing white petrolatum, jojoba oil, coconut oil, or almond oil within the past week. 5. People with a known diagnosis of ichthyosis. 6. A subject who, in the opinion of the investigator, will be un-cooperative or unable to comply with study procedures. 7. Subject unable to speak or read the English language, since all consents and instructions will be provided in English. 8. Those that are prisoners or cognitively impaired

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

4 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Active Comparator
All subjects will apply virgin coconut oil to a previously randomize section of the skin on the left or right forearm.

Group II

Active Comparator
All subjects will apply virgin jojoba oil to a previously randomize section of the skin on the left or right forearm

Group III

Active Comparator
All subjects will apply virgin almond oil to a previously randomize section of the skin on the left or right forearm

Group IV

Active Comparator
All subjects will apply white petrolatum ointment to a previously randomize section of the skin on the left or right forearm.

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 2 locations

Suspended

University of Arizona, Banner-University Medical Center

Tucson, United StatesOpen University of Arizona, Banner-University Medical Center in Google Maps
Suspended

University of California, Davis

Sacramento, United States
Completed2 Study Centers
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