Completed

Conjugated Linoleic Acid (CLA) Depletion-repletion: Metabolism and Bioactivity in Humans

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

CLA depletion-repletion

Dietary Supplement
Who is being recruted

Pathologic Processes

+ Pathological Conditions, Signs and Symptoms

+ Inflammation

From 20 to 40 Years
+8 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: July 2009
See protocol details

Summary

Principal SponsorAlexandre Guedes Torres
Last updated: May 3, 2013
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2009

Actual date on which the first participant was enrolled.

After collecting baseline blood samples, CLA-depletion phase started with dietary orientation, by a registered dietitian, to the study subjects (n=29) to exclude from their diets any type of dairy fat for the following 8 weeks. Blood samples were taken at the end of CLA-depletion, and CLA-repletion phase was initiated by dietitians' instructions: volunteers returned to their regular diets, and additionally consumed a CLA-enriched butter for another 8-week period. Blood samples were taken at the end of the CLA-repletion phase. The effects of CLA on the following parameters were evaluated: inflammatory mediators; fatty acid composition of erythrocytes, plasma phospholipids and cholesterol esters; body composition; clinical factors associated with the metabolic syndrome and indicators of cell membranes' stability.

NCT01841645
Principal SponsorAlexandre Guedes Torres
Last updated: May 3, 2013
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

29 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 20 to 40 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Pathologic ProcessesPathological Conditions, Signs and SymptomsInflammation

Criteria

3 inclusion criteria required to participate
20 to 40 years
BMI between 18.0 and 29.9 kg/m2
Healthy volunteers
5 exclusion criteria prevent from participating
Alcoholic
History of chronic disease
Smoker
Under medication
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Federal University of Rio de Janeiro

Rio de Janeiro, BrazilOpen Federal University of Rio de Janeiro in Google Maps
CompletedOne Study Center