Alternative Imaging Methods for Monitoring Neoadjuvant Therapy Response in Locally-Advanced Breast Cancer

This study focuses on women with locally-advanced breast cancer who are receiving treatment. The main goal is to find out if four new imaging techniques can effectively monitor how the cancer responds to the treatment. These techniques include MRI Elasticity Imaging (MRE), Electrical Impedance Spectroscopy (EIS), Microwave Imaging and Spectroscopy (MIS), and Near Infrared Spectroscopy (NIR). These methods create pictures of the inside of the breast, helping doctors see if the cancer is shrinking. The study also involves comparing these new methods to each other and to current standard imaging techniques. During the study, participants undergo imaging using the four new methods and possibly additional standard imaging techniques like contrast-enhanced MRI and mammography. These extra exams are only done if they are medically necessary for the patient's care. The study's primary outcome is to compare changes seen in the new imaging methods with changes seen in the standard methods. This comparison helps researchers understand if the new methods accurately show how the cancer responds to treatment.