Suspended

Clinical Study on Zirconia Bridges

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What is being tested

zirconia bridge restoration

Procedure
Who is being recruted

Congenital Abnormalities+4

+ Stomatognathic Diseases

+ Congenital, Hereditary, and Neonatal Diseases and Abnormalities

From 18 to 70 Years
See all eligibility criteria
How is the trial designed

Treatment Study

Interventional
Study Start: January 2010
See protocol details

Summary

Principal SponsorUniversity of Siena
Last updated: July 8, 2014
Sourced from a government-validated database.Claim as a partner

Study start date: January 1, 2010

Actual date on which the first participant was enrolled.

To evaluate the clinical performance and survival rate of NobelProceraTM Bridge Shaded Zirconia on natural teeth in the posterior region for a period of 5 years. The working hypothesis of this clinical study is that industrial centrally produced 3- or 4-unit bridges of shaded yttrium-oxide partially-stabilized (Y-TZP) zirconia (NobelProceraTM Shaded Zirconia) in combination with a veneering ceramic material will show sufficient CDA ratings (80% R+S) and a sufficient survival rate (93%) after 5 years in comparison with a reference level of 95%.

Principal SponsorUniversity of Siena
Last updated: July 8, 2014
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

9 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Congenital AbnormalitiesStomatognathic DiseasesCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesTooth AbnormalitiesTooth DiseasesStomatognathic System AbnormalitiesAnodontia

Criteria

Inclusion Criteria: The subject must be at least 18 (or age of consent), and less than 70 at the time of inclusion. The subject is healthy and compliant with good oral hygiene The subject is in need of a posterior fixed partial denture restoration of up to 4 units distal of the canines in the maxilla or mandible. The subject shall have a stable occlusal relationship with a fully restored, fixed opposing dentition. Obtained informed consent from the subject the subject should be available for the 5-year term of the investigation. No apical disorder or inflammation of abutment teeth, adjacent and opposing teeth. Good gingival / periodontal / periapical status of restoring, opposing and adjacent teeth. Healed situation of soft tissue augmentation is allowed. The subject should be available for the 5-year term of the investigation. Exclusion Criteria: The subject is not able to give her/his informed consent to participate. Alcohol or drug abuse as noted in patient records or in patient history. Reason to believe that the treatment might have a negative effect on the patient's total situation (psychiatric problems), as noted in patient records or in patient history. An existing condition where acceptable retention of the restoration is impossible to attain Mobility of the tooth to be restored. Pathologic pocket formation of 4 mm or greater around the tooth to be restored Severe bruxism or other destructive habits Amount of attached soft tissue is insufficient (no attached gingiva on the buccal side of the tooth). Health conditions, which do not permit the restorative procedure

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
The device is a ceramic core made of shaded zirconium with an anatomic contour core with a minimum of 0.6 mm** thickness and minimal connector size of 4.0 x 3.0 / 9.4 (height x width [mm] / area [mm2])** of high strength zirconia framework providing homogenous veneering material thickness as an external coating with 1.0 - 2.0 mm* wall thickness. The core is veneered with dental porcelain at the dental laboratory. Intended use and indications: NobelProceraTM Bridge Shaded Zirconia consists of an individualized, supporting substructure in a ceramic bridge construction for tooth/teeth replacement. NobelProceraTM Bridge Zirconia is intended for patients in need of prosthetic oral reconstruction in order to restore chewing function. Zirconia bridges for natural tooth restorations are customized, designed, and milled from pre-sintered blanks of zirconia. The multi-unit restorations can be placed in all positions in the mouth.

Study Objectives

Primary Objectives

Study Centers

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