Neural Functioning of Feeding Centers in Obese Youth
Data Collection
Collected from today forward - ProspectiveBehavior+12
+ Behavior, Animal
+ Body Weight
Case-Control
Comparing exposures between individuals with and without disease in order to identify potential risk factors.Summary
Study start date: July 1, 2010
Actual date on which the first participant was enrolled.Functional Magnetic Resonance Imaging (fMRI) provides a non-invasive method to assess the functional pathways affected by nutrient ingestion and therefore can help answer important questions regarding potential differences in the response of brain regions involved in feeding.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.51 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Case-Control
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 12 to 17 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Inclusion Criteria: Obese adolescents Good general health, taking no medication on a chronic basis Age 12 to 17 yrs, in puberty (girls and boys: Tanner stage II - IV) Obese Insulin Resistant Adolescents (BMI> 95th) (WBISI<1.2 plus a low adiponectin <6 ug/dl and high triglyceride levels >130mg/dl) Obese Insulin Sensitive Adolescents (BMI>95th) (WBISI >3) plus high adiponectin >8 ug/ml and triglyceride levels > 80 mg/dl Girls who begin menstruating must have a negative pregnancy test during the study Eligibility criteria for healthy non-obese children and adolescents: Brother or sister with obesity Age 12 to 17 years Normal fasting glucose and lipids in the child, and normal OGTT No use of any medication known to affect glucose, lipid metabolism and inflammation No endocrinopathies No use of any antipsychotic medication BMI >25th to <75th ( Center for Disease Control (CDC) BMI Charts) Minimum weight of 90lbs (CDC Growth Charts) Exclusion Criteria Baseline creatinine >1.0 mg Pregnancy Presence of endocrinopathies (e.g. Cushing syndrome) Cardiac or pulmonary or other significant chronic illness Adolescents with psychiatric disorder or with substance abuse determined via self-report. Use of anorexic agents No metal implants
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.3 intervention groups are designated in this study
This study does not include a placebo group
Treatment Groups
Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location