IMMUNEImmune Enhancement for Immunological Non-responders to ART

There will be up to eleven study visits and three telephone visits. All study procedures are for research purposes. All study subjects will receive the nutritional supplements zinc and SAMe. During the study you will be asked to answer questions about your alcohol use and smoking history. You will have exhaled breath tests, blood draws, physical exams, and bronchoscopies. Your medical records will be reviewed during the study. If you are a woman of childbearing age, a urine pregnancy test will be done at each study visit. Visit 1 (screening visit): This visit will last about 2 hours. At this visit you will: Have a physical exam Review your medical history Review your medications Have blood drawn Have a urine pregnancy test for women of child-bearing age Complete a survey about your alcohol use and smoking history. Discuss and schedule a bronchoscopy for the next visit You may not be eligible to continue in the study if the blood work done at visit one is not within normal limits or if you are pregnant. A study team member will contact you to let you know if you do or do not qualify to participate in the remainder of the study. Visit 2: This visit will last about 6 hours and will take place at the Hospital. At this visit you will: Have a physical exam Have blood drawn Have a urine pregnancy test for women of child-bearing age Do an exhaled breath test Have a bronchoscopy Receive nutritional supplements and education Treatment: The nutritional supplements zinc and SAMe will be given to you by the study team at visit 2. You will be asked to take the tablets once a day. If you experience upset stomach, abdominal cramps, diarrhea, or other uncomfortable side effects, we will reduce the amount of the nutritional supplements. If you are unable to tolerate the nutritional supplements, you will be withdrawn from the research study. Visits 3, 4, and 5 -Telephone Contact: You will receive a telephone call at one, two, and three weeks after visit 2 to ask you how you are tolerating the study supplements. If you are experiencing side effects such as upset stomach, abdominal cramps, or diarrhea, we will instruct you to decrease the dose of the supplements. Visits 6, 7, and 8 (months one, two, and three): These visits will last about 30 minutes and will be scheduled two months apart. At this visit you will: Have blood drawn Have a urine pregnancy test for women of child-bearing age Do an exhaled breath test Answer questions about how you are tolerating the nutritional supplements Receive nutritional supplements and education If your exhaled breath test is at goal at visit 6, you will continue to take the dietary supplements for one year from this point forward. If your exhaled breath test is not at goal at visit 6, you will be asked to return for visit 7. If your exhaled breath test is at goal at visit 7, you will continue to take the dietary supplements for one year from this point forward. If your exhaled breath test is not at goal at visit 7, you will be asked to return for visit 8. You will be asked to take the nutritional supplements for one year from this point forward. Visits 9 through 13: These visits will last about 30 minutes and will be scheduled two months apart. At this visit you will: Have blood drawn Have a urine pregnancy test for women of child-bearing age Answer questions about how you are tolerating the nutritional supplements Receive nutritional supplements and education Visit 14: This is the final study visit. It will last about 6 hours and will take place at the Hospital. At this visit you will: Have a physical exam Have blood drawn Have a urine pregnancy test for women of child-bearing age Do an exhaled breath test Have a bronchoscopy procedure Return unused nutritional supplements