Completed

KhoalaAssociation Between Digital Osteoarthritis and Lower Limb Osteoarthritis (Knee and Hip) in Severity and Evolution - Khoala Group Ancillary Project

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Study Aim

This study aims to investigate the association between digital osteoarthritis and lower limb osteoarthritis (knee and hip) in terms of severity and evolution, using the Kellgren and Lawrence score.

What is being tested

Hand X-rays

Radiation
Who is being recruted

From 40 to 75 Years
+5 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: November 2013
See protocol details

Summary

Principal SponsorCentre Hospitalier Universitaire de Nice
Last updated: March 31, 2026
Sourced from a government-validated database.Claim as a partner

Study start date: November 4, 2013

Actual date on which the first participant was enrolled.

This study investigates the connection between digital osteoarthritis (a condition affecting the joints in the fingers) and lower limb osteoarthritis (a condition affecting the knee and hip joints). The research aims to understand the severity and evolution of these conditions, especially considering the link between obesity and digital osteoarthritis, and the potential connection between digital osteoarthritis and the progression of knee osteoarthritis. The study focuses on a diverse group of individuals with symptomatic knee and hip osteoarthritis, representative of the general population. The ultimate goal is to gather more comprehensive data to confirm previous findings and contribute to a better understanding of these conditions. Participants in this study undergo a series of evaluations, including X-ray imaging and clinical and biological assessments of their hips and/or knees. The primary outcome measured is the Kellgren and Lawrence score, a standard method used to assess the severity of osteoarthritis in the hip or knee joints. This score helps researchers determine the progression of the condition and evaluate the effectiveness of various treatment strategies.

Principal SponsorCentre Hospitalier Universitaire de Nice
Last updated: March 31, 2026
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

479 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.



Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 40 to 75 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

3 inclusion criteria required to participate
men or women aged 40 to 75 years

with a confirmed diagnosis (criteria of the American College of Rheumatology :ACR) and Kellgren and Lawrence radiological stage >= 2

with symptomatic osteoarthritis of the hip and / or knee (femoro-tibial), unilateral or bilateral

2 exclusion criteria prevent from participating
osteotomy in the past

painful hip or knee prosthesis

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

patients with digital arthrosis and hip/knee arthrosis will practice hand X-rays

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Department of rheumatology, nice university hospital

Nice, FranceOpen Department of rheumatology, nice university hospital in Google Maps
CompletedOne Study Center