Suspended
Effects of Ischemic Postconditioning on Expression of Apoptosis-related MicroRNAs and Genes in Human Double Valve Replacement
What is being tested
double valve replacement
+ heart-lung machine
+ Aortic cross-clamp
ProcedureDevice
Who is being recruted
Over 20 Years
+9 Eligibility Criteria
How is the trial designed
Basic Science Study
Placebo-Controlled
Interventional
Study Start: March 2013
Summary
Principal SponsorCentral South University
Study ContactWanjun Luo, MDMore contacts
Last updated: March 5, 2013Sourced from a government-validated database.Claim as a partner
Study start date: March 1, 2013
Actual date on which the first participant was enrolled.Cardiopulmonary bypass and cardioplegic arrest could regulate expression of microRNAs in patients undergoing double valve replacement (aortic and mitral). The modulation of myocardial microRNAs by cardiopulmonary bypass and cardioplegic arrest may be rescued by ischemic postconditioning. Downstream effectors would also be affected.
Principal SponsorCentral South University
Study ContactWanjun Luo, MDMore contacts
Last updated: March 5, 2013Sourced from a government-validated database.Claim as a partner
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Design Details
8 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Basic Science Study
Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Criteria
Any sex
Biological sex of participants that are eligible to enroll.Over 20 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Criteria
1 inclusion criteria required to participate
Consecutive eight patients with rheumatic heart valve disease undergoing elective double valve replacement(aortic and mitral)are considered for participation in this study
8 exclusion criteria prevent from participating
emergency and reoperations
hypertension
infective valve disease
insulin-dependent diabetes mellitus
Show More Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Treatment Groups
Study Objectives
2 intervention groups are designated in this study
50% chance of being blinded to the placebo group
Treatment Groups
Group I
ShamPatients undergoing double valve replacement (aortic and mitral).
Group II
ExperimentalPatients undergoing double valve replacement (aortic and mitral) with ischemic postconditioning.
Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
SuspendedOne Study Center