Completed

Transcriptome, Proteome and Metabolome Analysis of Atherosclerotic Plaques in Leg Arteries

Study Aim

This study aims to analyze the role of biofilm in the hardening of arteries, specifically in legs affected by vascular disease and/or diabetes, by examining atherosclerotic plaques using transcriptome, proteome, and metabolome approaches to gain valuable insights into the wound's microecology.

What is being collected

Data Collection

Collected from today forward - Prospective

Who is being recruted

Arterial Occlusive Diseases+7

+ Arteriosclerosis

+ Cardiovascular Diseases

+3 Eligibility Criteria

See all eligibility criteria

How is the trial designed

Case-Only

Examining characteristics of individuals with a disease in order to identify genetic or environmental factors contributing to the condition.

Observational

Study Start: June 2012

See protocol details

Summary

Principal SponsorSouthwest Regional Wound Care Center

Last updated: June 29, 2018

Sourced from a government-validated database.Claim as a partner

Study start date: June 1, 2012

Actual date on which the first participant was enrolled.

High throughput pyrosequencing is opening new doors in nucleic acid analysis. 454 Roche has developed sequencing instrumentation which has the ability to sequence not only genomic DNA (gDNA) but also derivatives of messenger RNA (mRNA) and 16s ribosomal DNA (rDNA). This technology has the potential to survey the nucleic acids involved within a mixed population of species, such as atherosclerotic biofilm. In addition to transcriptome science; proteome, metabolome, and other -omic sciences are advancing rapidly. Examining atherosclerotic plaque using transcriptome, proteome, metabolome, and other -omic approaches may provide valuable insight into the wound's microecology.

NCT01803126

Principal SponsorSouthwest Regional Wound Care Center

Last updated: June 29, 2018

Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Design Details

10 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Case-only

These studies focus only on individuals who have a specific disease. Researchers examine patterns—often genetic or environmental—to uncover what might be linked to the condition.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.

Conditions

Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Arterial Occlusive DiseasesArteriosclerosisCardiovascular DiseasesEndocrine System DiseasesMetabolic DiseasesNutritional and Metabolic DiseasesGlucose Metabolism DisordersDiabetes MellitusVascular DiseasesAtherosclerosis

Criteria

2 inclusion criteria required to participate

The subject must be 18 years of age or older

The subject with identifying leg or legs that were amputated for vascular disease and/or diabetes

1 exclusion criteria prevent from participating

The subject will be excluded if they have had a traumatic amputation which did not involve vascular disease and/or diabetes

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.

Treatment Groups

Study Objectives

One single intervention group is designated in this study

This study does not include a placebo group

Treatment Groups

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Southwest Regional Wound Care Center

Lubbock, United StatesOpen Southwest Regional Wound Care Center in Google Maps

CompletedOne Study Center