Completed

The Role of Acute Total Sleep Deprivation in the Regulation of Metabolism, Neuroendocrine Responses, and Behavioral Measures

0 criteria met from your profileSee at a glance how your profile meets each eligibility criteria.
What is being tested

Inhibitory task

+ Blood samples

+ Tissue samples

BehavioralProcedure
Who is being recruted

Mental Disorders+5

+ Nervous System Diseases

+ Neurologic Manifestations

From 18 to 28 Years
+13 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: March 2013
See protocol details

Summary

Principal SponsorUppsala University
Last updated: December 9, 2013
Sourced from a government-validated database.Claim as a partner

Study start date: March 1, 2013

Actual date on which the first participant was enrolled.

It is predicted that acute total sleep deprivation will affect gene expression and DNA methylation. It is also predicted that sleep deprivation will up-regulate ghrelin, and affect other neuroendocrine markers and hormones in a negative manner. It is further predicted that sleep deprivation will decrease participants' memory performance.

NCT01800253
Principal SponsorUppsala University
Last updated: December 9, 2013
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

17 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Male

Biological sex of participants that are eligible to enroll.

From 18 to 28 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Mental DisordersNervous System DiseasesNeurologic ManifestationsSigns and SymptomsSleep Wake DisordersPathological Conditions, Signs and SymptomsDyssomniasSleep Deprivation

Criteria

5 inclusion criteria required to participate
Age 18-28y
Healthy (self-reported) and not on medication
Male
Non-smoking
Show More Criteria
8 exclusion criteria prevent from participating
Any dietary issues with the food items provided
Any sleep conditions (e.g. irregular bedtimes, sleep complaints)
Current or history of endocrine, neurological or psychiatric disorders
Major illness
Show More Criteria

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Participants will be required to stay up for the entire night before 'Blood Samples' and 'Tissue samples' will be taken and the 'Portion Size Task' and 'Inhibitory task' will be performed. This will then be followed by the 'Oral glucose tolerance test' with additional 'Blood Samples' to be taken as described for that test.

Group II

Experimental
Participants will have an 8-h sleep opportunity before 'Blood Samples' and 'Tissue samples' will be taken and 'Portion Size Task' and 'Inhibitory task' will be performed. This will be followed by the 'Oral glucose tolerance test' with additional 'Blood Samples' to be taken as described for that test.

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Department of Neuroscience, Uppsala University

Uppsala, SwedenOpen Department of Neuroscience, Uppsala University in Google Maps
CompletedOne Study Center