Suspended

Enhancing Bioavailability and Nutritional Quality of Processed Tomato Products

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What is being tested

Tangerine tomato juice

+ Red tomato juice

Other
Who is being recruted

From 18 to 70 Years
+20 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Basic Science Study

Interventional
Study Start: October 2012
See protocol details

Summary

Principal SponsorOhio State University
Last updated: October 20, 2025
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Study start date: October 1, 2012

Actual date on which the first participant was enrolled.

The primary goal of this research is to determine if a processed Tangerine tomato product has enhanced bioavailability of carotenoids and flavonoids compared to a commercially available processed red tomato product in humans. This primary objective will be accomplished by quantifying carotenoids from post-prandial triglyceride-rich lipoprotein (TRL) fractions of plasma and flavonoids from whole plasma and urine, after subjects consume a meal containing Tangerine or red tomato juice. A secondary goal is to examine if short-term delivery of bioactives from Tangerine and red tomatoes impact markers of inflammation in humans. This secondary objective will be accomplished by analyzing plasma for both interleukin-6 (IL-6), a marker for inflammation, and RNA to assess alterations in transcription of genes that regulate inflammation.

NCT01696773
Principal SponsorOhio State University
Last updated: October 20, 2025
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

12 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Basic Science Study

Basic science studies help researchers understand how the body works or how a disease develops. They don't test treatments, but they build the foundation for future therapies.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 70 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

5 inclusion criteria required to participate
Age 18-70 years
BMI 18.5 to 30.0kg/m2
Not anemic (hemoglobin at or above 10g/dL and hematocrit at or above 30%)
Total cholesterol <= 200 mg/dL
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15 exclusion criteria prevent from participating
Allergies to tomatoes or tomato products
Anemia (hemoglobin below 10g/dL or hematocrit below 30%)
Auto-immune disorders
Blood donation within the last 8 weeks
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Group I

Experimental
Tangerine tomato juice will be fed

Group II

Experimental
Red tomato juice will be fed

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

The Ohio State University Clinical Research Center

Columbus, United StatesOpen The Ohio State University Clinical Research Center in Google Maps
SuspendedOne Study Center