AMORCE-CBPMorphometric Analysis of Sputum Cytology and Biomarkers for Lung Cancer Screening in Asbestos-Exposed Workers

This study focuses on workers who have been highly exposed to asbestos, a group at high risk for lung cancer. Currently, these workers undergo repeated CT-scans for medical follow-ups, which are more effective at detecting peripheral lesions but expose individuals to radiation and risk of false-positives. The study aims to explore the potential benefits of analyzing sputum using automated cytometry, either alone or combined with CT-scans, to improve lung cancer screening in this population. The study also includes an ancillary study to evaluate the potential of blood predictive biomarkers for lung cancer. Participants in this study will provide sputum samples for analysis using automated cytometry, a method that examines cells in the sputum. The study measures the sensitivity of this method for detecting lung cancer compared to conventional cytology analysis of sputum. Additionally, the study evaluates the risk of false-positives for lung cancer detection using this method in comparison to conventional cytology analysis. The ancillary study involves blood tests to assess potential predictive biomarkers for lung cancer.