Completed

The Influence of Apolipoprotein C3 Variants on Liver Steatosis and Serum Liver Enzyme Values in Obese Children

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What is being collected

Data Collection

Collected from today forward - Prospective
DNA Samples
Who is being recruted

Body Weight+8

+ Digestive System Diseases

+ Liver Diseases

From 6 to 18 Years
+6 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: July 2012
See protocol details

Summary

Principal SponsorFar Eastern Memorial Hospital
Last updated: March 17, 2015
Sourced from a government-validated database.Claim as a partner

Study start date: July 1, 2012

Actual date on which the first participant was enrolled.

The primary aim of this study is to assess the associations between to investigate the association of rs2854117 C > T and rs2854116 T > C SNPs of the APOC3 gene with liver steatosis, as measured by liver ultrasound. As a secondary aim, the investigators will examine the associations between APOC3 rs2854117 C > T and rs2854116 T > C SNPs and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. In addition, the investigators will further analyze the association with other biomarkers, such as body mass index, adiponectin and insulin resistance.

NCT01682655
Principal SponsorFar Eastern Memorial Hospital
Last updated: March 17, 2015
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

500 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 6 to 18 Years

Range of ages for which participants are eligible to join.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Body WeightDigestive System DiseasesLiver DiseasesNutrition DisordersNutritional and Metabolic DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsOvernutritionOverweightFatty LiverObesity

Criteria

3 inclusion criteria required to participate
Age 6-18 years old
Obesity definition: BMI > 95% according to the age- and gender-specific standard suggested by National Health Institute in Taiwan
Willing to give written informed consent by parents
3 exclusion criteria prevent from participating
Alcohol consumption
Chronic liver diseases, including hepatitis B, hepatitis C, Wilson disease and autoimmune hepatitis
Major systemic diseases, including cardiopulmonary disease, renal failure, cancer, and psychotic disorder

Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Study Objectives

Study Objectives

Primary Objectives

Secondary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

Far Eastern Memorial Hospital

New Taipei City, TaiwanOpen Far Eastern Memorial Hospital in Google Maps
CompletedOne Study Center