Completed

Nutrient Regulation of Amino Acid Transporters in Aging Human Skeletal Muscle

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What is being collected

Data Collection

Collected from today forward - Prospective
Who is being recruted

From 18 to 75 Years
+27 Eligibility Criteria
See all eligibility criteria
How is the trial designed

Cohort

Tracking disease incidence in order to identify risk factors and understand disease progression over time.
Observational
Study Start: December 2011
See protocol details

Summary

Principal SponsorUniversity of Utah
Last updated: November 16, 2016
Sourced from a government-validated database.Claim as a partner

Study start date: December 1, 2011

Actual date on which the first participant was enrolled.

The goal of the research project is to determine how aging and inactivity reduce the muscle anabolic effect of nutrients and lead to muscle and functional loss. The central hypothesis is that aging reduces mTORC1 signaling and the expression of skeletal muscle amino acid transporters in response to anabolic stimulation leading to reduced muscle adaptation to increased intracellular amino acid requirements. The investigators further hypothesize that inactivity exacerbates this effect with significant muscle and functional loss, and rehabilitation restores muscle signaling, metabolism and function to baseline values.

NCT01669590
Principal SponsorUniversity of Utah
Last updated: November 16, 2016
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.
Design Details

28 patients to be enrolled

Total number of participants that the clinical trial aims to recruit.

Cohort

These studies follow a group of individuals with common characteristics (such as a condition or birth year) over a specific period to study health outcomes or exposures.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

From 18 to 75 Years

Range of ages for which participants are eligible to join.

Healthy volunteers allowed

If individuals who are healthy and do not have the condition being studied can participate.

Criteria

1 inclusion criteria required to participate
Age between 18-35 and 60-75 yrs 2. Ability to sign informed consent 3. Mini-mental state exam score > 26 4. Free-living, prior to admission
26 exclusion criteria prevent from participating
A history of > 20 pack per year smoking
A recent history ( < 12 months) of GI bleed
Agitation/aggression disorder (by psychiatric history and exam)
Alcohol or drug abuse
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Study Plan

Find out more about all the medication administered in this study, their detailed description and what they involve.
Treatment Groups
Study Objectives

2 intervention groups are designated in this study

This study does not include a placebo group 

Treatment Groups

Study Objectives

Primary Objectives

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.

This study has 1 location

The University of Utah

Salt Lake City, United StatesOpen The University of Utah in Google Maps
CompletedOne Study Center