Completed
Usefulness of Myocardial Deformation Imaging in Breast Cancer Patients Treated With Trastuzumab for Early Detection of Myocardial Dysfunction
What is being collected
Data Collection
Collected from today forward - ProspectiveDNA Samples
Who is being recruted
Cardiovascular Diseases+6
+ Heart Diseases
+ Pathologic Processes
From 18 to 75 Years
+6 Eligibility Criteria
How is the trial designed
Case-Only
Examining characteristics of individuals with a disease in order to identify genetic or environmental factors contributing to the condition.Observational
Study Start: July 2011
Summary
Principal SponsorSeoul National University Hospital
Last updated: April 29, 2014
Sourced from a government-validated database.Claim as a partner
Study start date: July 1, 2011
Actual date on which the first participant was enrolled.The investigators will prospectively evaluate whether changes in tissue deformation, assessed by myocardial strain and strain rate (SR) and identify possibility of early detection of LV dysfunction in patients treated with trastuzumab.
Principal SponsorSeoul National University Hospital
Last updated: April 29, 2014
Sourced from a government-validated database.Claim as a partner
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.Design Details
120 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Case-only
These studies focus only on individuals who have a specific disease. Researchers examine patterns—often genetic or environmental—to uncover what might be linked to the condition.
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Conditions
Criteria
Female
Biological sex of participants that are eligible to enroll.From 18 to 75 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Cardiovascular DiseasesHeart DiseasesPathologic ProcessesRadiation InjuriesPathological Conditions, Signs and SymptomsWounds and InjuriesChemically-Induced DisordersDrug-Related Side Effects and Adverse ReactionsCardiotoxicity
Criteria
1 inclusion criteria required to participate
HER2(+) breast cancer, anticipating Trastuzumab therapy
5 exclusion criteria prevent from participating
Congenital heart disease
Poor sonic window
Refusal to informed consent
Regional wall motion abnormality (+) in echocardiography
Show More Criteria
Study Plan
Find out more about all the medication administered in this study, their detailed description and what they involve.Study Objectives
Study Objectives
Primary Objectives
Secondary Objectives
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location
Seoul National University Hospital
Seoul, South KoreaOpen Seoul National University Hospital in Google MapsCompletedOne Study Center