Assessment of Cardiac and Paroxysmal Abnormalities in Rett Syndrome Patients
Data Collection
Intellectual Disability+13
+ Congenital, Hereditary, and Neonatal Diseases and Abnormalities
+ Nervous System Diseases
Summary
Study start date: August 1, 1995
Actual date on which the first participant was enrolled.PROTOCOL OUTLINE: Patients receive an electrocardiogram at baseline and every 6 months for 3 years. Clinical stage II patients undergo 24-hour Holter monitoring on the same schedule; age-matched controls are tested once. A group of patients with more than 1 seizure or possible seizure every 5 days undergo 5-day continuous electroencephalogram/polygraphic/video monitoring, with respiratory effort assessment, end tidal carbon dioxide and oxygen saturation levels, and a seizure log.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.95 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Female
Biological sex of participants that are eligible to enroll.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Classical Rett syndrome meeting Rett Syndrome Diagnostic Work Group criteria Age-matched girls without neurologic or cardiac problems entered as controls