Completed

Chronic Infusional Epoprostenol for Severe Primary Pulmonary Hypertension

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What is being tested

epoprostenol

Drug
Who is being recruted

Cardiovascular Diseases+8

+ Lung Diseases

+ Pathologic Processes

See all eligibility criteria
How is the trial designed

Treatment Study

Phase 4
Interventional
Study Start: August 1993
See protocol details

Summary

Principal SponsorNational Center for Research Resources (NCRR)
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner

Study start date: August 1, 1993

Actual date on which the first participant was enrolled.

PROTOCOL OUTLINE: Patients are treated with a chronic continuous infusion of epoprostenol. The highest tolerated infusion rate is determined for each patient by gradually increasing the rate until the target dose is reached or the patient experiences at least 1 dose-limiting effect. Patients are subsequently treated with a chronic continuous infusion, beginning at a rate below the highest tolerated rate. Attempts are made to increase the dose to the highest tolerated rate over the first 72 hours.

NCT00004754
Principal SponsorNational Center for Research Resources (NCRR)
Last updated: June 24, 2005
Sourced from a government-validated database.Claim as a partner

Protocol

This section provides details of the study plan, including how the study is designed and what the study is measuring.

Treatment Study

These studies test new ways to treat a disease, condition, or health issue. The goal is to see if a new drug, therapy, or approach works better or has fewer side effects than existing options.

Eligibility

Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.
Conditions
Criteria

Any sex

Biological sex of participants that are eligible to enroll.

Healthy volunteers not allowed

If individuals who are healthy and do not have the condition being studied can participate.

Conditions

Pathology

Cardiovascular DiseasesLung DiseasesPathologic ProcessesPathological Conditions, Signs and SymptomsVascular DiseasesDisease AttributesHypertensionHypertension, PulmonaryRespiratory Tract DiseasesRare DiseasesFamilial Primary Pulmonary Hypertension

Criteria

PROTOCOL ENTRY CRITERIA: Severe primary pulmonary hypertension Able to prepare and self-administer medication

Study Centers

These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.
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CompletedNo study centers