AMPA Receptor Blockade With LY300164 in the Treatment of Parkinson's Disease

Study start date: February 1, 2000

Males and females between the ages of 30 and 75 are eligible for the study. All will carry the diagnosis of idiopathic Parkinson's disease based on the presence of a characteristic clinical history and neurological findings. All will have relatively advanced disease (Hoehn and Yahr Stages II to IV) with levodopa-associated motor response complications, including wearing-off fluctuations and peak-dose dyskinesias. No presence or history of any medical condition that can reasonably be expected to subject the patient to unwarranted risk. No clinically significant laboratory abnormalities including liver enzyme elevations more than three times the upper limit of normal, or neutropenia (WBC less than 4000). No parkinson's disease patients exhibiting diphasic or end-of-dose dyskinesias or disabling dystonia. Since LY300164 is an inhibitor of CP4503A4, patients receiving certain drugs metabolized by that pathway will not be included. No patients who are unable to be treated with levodopa/carbidopa alone or a single, relatively short-acting dopamine agonist. No patients who require additional treatment with amantadine or other concomitant medications. No pregnant women or those not practicing effective means of birth control since the influence of any investigational compound on the unborn child and reproductive organs is unknown.