Pituitary Evaluation in Familial Dwarfism of Sindh
This study aims to observe and understand the pituitary function in individuals from Sindh who have familial dwarfism.
Data Collection
Bone Diseases+14
+ Bone Diseases, Developmental
+ Bone Diseases, Endocrine
Summary
Study start date: September 1, 1995
Actual date on which the first participant was enrolled.PROTOCOL OUTLINE: Pituitary size and anatomy and growth hormone response are evaluated. All patients undergo MRI of the pituitary fossa on day 1. On day 2, homozygous patients receive a slow infusion of normal saline with blood sampling every 10 minutes.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.4 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Any sex
Biological sex of participants that are eligible to enroll.From 10 to 60 Years
Range of ages for which participants are eligible to join.Healthy volunteers not allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Familial Dwarfism of Sindh Severe short stature but proportionate without dysmorphic features Normal body size and weight at birth Bone age is severely delayed Puberty is somewhat delayed (age 15-16) Fertility present in at least 3 dwarfs